IADR Abstract Archives
Minor salivary gland biopsy: A reliable test for the diagnosis of systemic amyloidosis
Objectives: Amyloidosis is a rare metabolic disorder of difficult diagnosis that occurs due to accumulation of localized or systemic amyloid substance. Oral manifestation of amyloidosis is rare but when it occurs, the tongue is usually the most involved anatomic site.
The aim of this study was to present clinic-pathological data of oral amyloidosis -affected patients in whom the systemic disorder was not recognized.
Methods: A retrospective study was conducted based on the records of oral amyloidosis-affected patients diagnosed in Department of oral medicine and surgery of the Teaching University Hospital of Sahloul between 2013 and 2017. The diagnosis was confirmed by minor salivary gland biopsy. The clinical and histopathological features were carried out and analyzed.
Results: Five patients were diagnosed with systemic amyloidosis, 3 males and 2 females. Their age was between 52 and 68. The tongue was affected. The sixth decade of life was mostly involved. The histopathology of the salivary glands confirmed glandular amyloid deposits in all lesions with apple-green birefringence under polarized light
Conclusions: Tongue infiltrate may be the first sign of systemic amyloid deposition. Minor salivary gland biopsy may help confirm the diagnosis in symptomatic cases, as it is noninvasive, easy to execute, and causes minimal discomfort to patients.
The aim of this study was to present clinic-pathological data of oral amyloidosis -affected patients in whom the systemic disorder was not recognized.
Methods: A retrospective study was conducted based on the records of oral amyloidosis-affected patients diagnosed in Department of oral medicine and surgery of the Teaching University Hospital of Sahloul between 2013 and 2017. The diagnosis was confirmed by minor salivary gland biopsy. The clinical and histopathological features were carried out and analyzed.
Results: Five patients were diagnosed with systemic amyloidosis, 3 males and 2 females. Their age was between 52 and 68. The tongue was affected. The sixth decade of life was mostly involved. The histopathology of the salivary glands confirmed glandular amyloid deposits in all lesions with apple-green birefringence under polarized light
Conclusions: Tongue infiltrate may be the first sign of systemic amyloid deposition. Minor salivary gland biopsy may help confirm the diagnosis in symptomatic cases, as it is noninvasive, easy to execute, and causes minimal discomfort to patients.