IADR Abstract Archives
Effect of Osteogenically Induced Gingival Fibroblasts Injection on Cementum Thickness
Objectives:
Methods:
Results:
Conclusions:
Orthodontically induced tooth root resorption is an unwanted result of orthodontic tooth movement that can be expressed by a reduction in cementum thickness. Our aim was to analyze the effect of intraligamentary injection of osteogenically induced gingival fibroblasts (OIGFs) on cellular and acellular cementum thickness in Beagle dogs during orthodontic treatment.
Methods:
Six Beagle dogs, were obtained and all upper and lower third and fourth premolars received mechanical loading induced orthodontic tooth movement for 4 weeks. Fifteen premolars were randomly assigned to one of the two groups; Control group which received a single injection of Dulbecco’s modified eagle’s medium in the periapical area [N = 8 teeth] and OIGF group which received a single OIGF injection through periodontal ligament near the root apex [N = 7 teeth]. Histological and histomorphometric analyses were performed using computer software. Thicknesses of cellular and acellular cementum were measured in 5 different zones along the root.
Results:
There were no statistically significant differences in cellular or acellular cementum thicknesses between the two groups (P>0.05).
Conclusions:
A single intraligamentary injection of OIGF did not increase the cementum thickness in Beagle dogs after orthodontic tooth movement, thereby not preventing orthodontically induced tooth root resorption.