IADR Abstract Archives
Does Concentrated Growth Factors (CGF) Coated Implants Improve Osseointegration?
Objectives: To examine the effect of Concentrated growth factors (CGF) on implant osseintegration in big animal model.
Methods: CGF-coated and uncoated dental implants were implanted in mandible of 6 male beagle dogs. Under general anesthesia, bi-lateral extraction of six mandibular teeth (premolars and molars) were performed using atraumatic surgical technique. Four to six weeks later, venous blood of each beagle dog was drawn into three costume-made implant centrifugation tubes centrifuged at 2700 rpm for 7-10 minutes, leading to production of CGF-coated implants. Next, each animal subject received CGF-coated implants at the right mandibular side and uncoated implants serving as controls were implanted at the left side. A CT examination was performed after implantation. At the end of the 6-weeks study, the implantation sites were harvested and the bone implant contact (BIC), defined as the direct bone-to-implant interface, was calculated by histological evaluation and Micro-CT scanning.
Results: BIC values obtained from histologic assessment and micro-CT analysis in the treatment group were greater than those of the control group. Mean BIC values were higher in the treatment group, compared to control group by micro-CT analysis. In addition, higher BIC values were determined by histomorphometric analysis in the treated sites
Conclusions: The use of CGF-coated implants shows superiority in osseintegration over the control group.
Methods: CGF-coated and uncoated dental implants were implanted in mandible of 6 male beagle dogs. Under general anesthesia, bi-lateral extraction of six mandibular teeth (premolars and molars) were performed using atraumatic surgical technique. Four to six weeks later, venous blood of each beagle dog was drawn into three costume-made implant centrifugation tubes centrifuged at 2700 rpm for 7-10 minutes, leading to production of CGF-coated implants. Next, each animal subject received CGF-coated implants at the right mandibular side and uncoated implants serving as controls were implanted at the left side. A CT examination was performed after implantation. At the end of the 6-weeks study, the implantation sites were harvested and the bone implant contact (BIC), defined as the direct bone-to-implant interface, was calculated by histological evaluation and Micro-CT scanning.
Results: BIC values obtained from histologic assessment and micro-CT analysis in the treatment group were greater than those of the control group. Mean BIC values were higher in the treatment group, compared to control group by micro-CT analysis. In addition, higher BIC values were determined by histomorphometric analysis in the treated sites
Conclusions: The use of CGF-coated implants shows superiority in osseintegration over the control group.