IADR Abstract Archives
Odontogenic Tumours: A 10 year retrospective study in a South African teaching hospital
Objectives: Odontogenic tumours (OTs) comprise a group of hamartomas, benign and malignant neoplasms arising from odontogenic epithelium entrapped within the jaws or in adjacent soft tissues. The first attempt by the World Health Organisation (WHO) to classify OTs was in 1971. This was followed by three revisions in 1992, 2005 and 2017 following developments in immunohistochemistry and molecular biology techniques.
The objective of the study was to determine the prevalence of OTs in the Department of Oral Pathology at the Wits Oral Health Centre (WOHC) from 2004 to 2013.
Methods: The histopathology records of 392 patients diagnosed with OTs at the Department of Oral Pathology, WOHC, during a 10-year period were reviewed and reclassified according to the 2017 WHO classification of OTs. Clinical data, including age, gender, and anatomical distribution of lesions, was collected and analysed.
Results: OTs accounted for 2.87% of all oral and maxillofacial lesions (n = 13665). There were 385(98.2%) benign OTs and 7(1.8%) malignant OTs, the latter comprised 6 carcinomas and 1 sarcoma. The 3 most common OTs in descending order of frequency were ameloblastoma 256(62%), cemento-ossifying fibroma 44 (11.22%) and odontogenic myxoma 29(7.40%).
Of all the OTs 122 (31.12%) occurred in the first three decades of life, with a peak incidence in the second decade 91 (23.21%).The mean age of patients with benign OTs was 27.31 years whereas the mean age for patients with malignant OTs was 47 years.
The male to female ratios for benign and malignant OTs were 1: 1.1 and 1:0.8 respectively. Both benign and malignant OTs showed a predilection for the posterior region of the mandible
Conclusions: Ameloblastoma was the most commonly seen odontogenic tumour. This finding is similar to those from Asian and African series. The variations observed between this study and those series are largely attributed to the 2017 WHO reclassification of OTs.
The objective of the study was to determine the prevalence of OTs in the Department of Oral Pathology at the Wits Oral Health Centre (WOHC) from 2004 to 2013.
Methods: The histopathology records of 392 patients diagnosed with OTs at the Department of Oral Pathology, WOHC, during a 10-year period were reviewed and reclassified according to the 2017 WHO classification of OTs. Clinical data, including age, gender, and anatomical distribution of lesions, was collected and analysed.
Results: OTs accounted for 2.87% of all oral and maxillofacial lesions (n = 13665). There were 385(98.2%) benign OTs and 7(1.8%) malignant OTs, the latter comprised 6 carcinomas and 1 sarcoma. The 3 most common OTs in descending order of frequency were ameloblastoma 256(62%), cemento-ossifying fibroma 44 (11.22%) and odontogenic myxoma 29(7.40%).
Of all the OTs 122 (31.12%) occurred in the first three decades of life, with a peak incidence in the second decade 91 (23.21%).The mean age of patients with benign OTs was 27.31 years whereas the mean age for patients with malignant OTs was 47 years.
The male to female ratios for benign and malignant OTs were 1: 1.1 and 1:0.8 respectively. Both benign and malignant OTs showed a predilection for the posterior region of the mandible
Conclusions: Ameloblastoma was the most commonly seen odontogenic tumour. This finding is similar to those from Asian and African series. The variations observed between this study and those series are largely attributed to the 2017 WHO reclassification of OTs.