Effect of Periodontal Treatment on Renal Function in T2DM

Method: Sixteen T2DM patients (mean age 61.9 ± 7.0, 15 males and 1 female) were randomly assigned into three groups: Group 1 (n=6) received supragingival scaling with ultrasonic devices, antimicrobial periodontal treatment (2% minocycline hydrochloride gel) and oral hygiene instruction at baseline and biweekly for 2 months; Group 2 (n=7) received the supragingival scaling with ultrasonic devices and oral hygiene instruction at baseline and biweekly for 2 months; Group 3 (control) (n = 3) received no periodontal treatment. At baseline and four months, periodontal examination as well as blood measurements were performed. Periodontal status pre- and post-treatment in each group was compared using Wilcoxon Signed-Rank test while mean eGFR were descriptively compared.

Result: Periodontal status improved with 52.3% reduction of pocket depth of ≥ 4 mm in group 1 (p = 0.02) and 40.9% of those in group2 (p = 0.04), respectively. Mean eGFR were altered from 69.2 to 66.8 ml/min (in group 1), 59.6 to 62.9 ml/min (in group 2), while 68.7 to 65.3 ml/min (in control group). Though positive changes of eGFR in group 2 were found, however, those in group 1 were inconclusive.

Conclusion: Our results indicated that periodontal treatment improve periodontal status, however we failed to find significant changes of eGFR in T2DM patients.