Association between polymorphism related type 2 diabetes mellitus and periodontitis
Objectives: Recently, it has been focus on the relationship of genetic polymorphism and development of type 2 diabetes mellitus. It has been reported that subjects with the G/G type of adiponectin SNP276 single-nucleotide polymorphisms (SNPs) had higher insulin resistance in Japanese. Human β3-adrenergic receptor (β3-AR) gene was also reported to be associated with increased capacity to insulin resistance. The aims of this study were to assess whether genotype of adiponectin G276T and β3-AR Trp64Arg relate to periodontitis in Japanese type 2 diabetes.
Methods: Forty-three type 2 diabetes subjects (26 males and 17 females; mean age, 61.7 ± 9.0 yrs) were enrolled to the study. All subjects received periodontal examination and blood sampling. Periodontal parameters, including probing depth (PD), attachment level and bleeding on probing (BOP), were measured at six sites per tooth. Serum adiponectin and serum high sensitive C-reactive protein were assayed by enzyme-immunoassay and latex nephrometry method, respectively. Genotypes of adiponectin G276T and β3-AR Trp64Arg were determined by Nuclease-mediated SNP Specific Ligation method.
Results: For adiponectin G276T, the G/G, G/T and T/T genotypes were found in 18, 24 and 1 subject, respectively. The serum level of hs-CRP was significantly higher in subjects with both G allele (G/G + G/T) of adiponectin G276T and Trp allele (Trp/Trp + Arg/Trp) of β3-AR Trp64Arg [SNP(+)] compared with those without these genotypes [SNP(-)] (0.109 ± 0.028 mg/dl vs. 0.033 ± 0.012 mg/dl, p＝0.016). In addition, BOP and percentage of sites with PD ≥ 6mm of the subjects in SNP(+) has also shown higher level than those in SNP(-) (14.9 ± 1.9% vs. 7.1 ± 1.2%, p = 0.001, 10.4 ± 2.1% vs. 5.0 ± 1.7%, p＝0.06).
Conclusion: Our results suggested that both adiponectin G276T and β3-AR Trp64Arg polymorphism might be associated with more advance periodontitis.
Division: World Congress on Preventive Dentistry
Meeting:2013 World Congress on Preventive Dentistry (Budapest, Hungary) Location: Budapest, Hungary
Year: 2013 Final Presentation ID:178 Abstract Category|Abstract Category(s):Posters
Authors
Hori-matsumoto, Sayaka
( Graduate School of Medical and Dental Sciences, Niigata University, Niigata, N/A, Japan
)
Ogawa, Hiroshi
( Graduate School of Medical and Dental Sciences, Niigata University, Niigata, N/A, Japan
)
Minagawa, Kumiko
( Graduate School of Medical and Dental Sciences, Niigata University, Niigata, N/A, Japan
)
Sato, Misuzu
( Graduate School of Medical and Dental Sciences, Niigata University, Niigata, N/A, Japan
)
Damrongrungruang, Teerasak
( Graduate School of Medical and Dental Sciences, Niigata University, Niigata, N/A, Japan
)
Hanyu, Osamu
( Graduate School of Medical and Dental Sciences, Niigata University, Niigata, N/A, Japan
)
Sone, Hirohito
( Graduate School of Medical and Dental Sciences, Niigata University, Niigata, N/A, Japan
)
Miyazaki, Hideo
( Graduate School of Medical and Dental Sciences, Niigata University, Niigata, N/A, Japan
)
SESSION INFORMATION
Poster Session
Poster Session III: Addressing Vulnerable Populations; Oral and Systemic Health Associations: From Science to Health Promotion Policies; HIV, oral infections and oral health
10/12/2013