IADR Abstract Archives
Stemcells Derived From Dental Periapical Lesions: Therapeutic Potential and Applications
Objectives: This systematic review aims to investigate the biological characteristics, differentiation potential, and therapeutic applications of stem cells derived from dental periapical lesions. The review focuses on evaluating their role in tissue regeneration and potential use in clinical settings.
Methods: A systematic literature search is conducted using databases including PubMed and Scopus, alongside hand-searching relevant journals. Studies on human dental periapical lesions and their derived stem cells were included, while animal studies, non-dental stem cell sources and teeth with communication to periodontal pockets were excluded. Data extraction focused on stem cell characteristics, differentiation capacity, and regenerative applications. The Cochrane Risk of Bias tool (RoB 2) is to be used to assess the risk of bias, and a narrative synthesis will be performed to summarize the findings.
Results: Stem cells from dental periapical lesions exhibit key stem cell markers and demonstrate strong differentiation potential into osteogenic, chondrogenic, and adipogenic lineages. Several studies report their successful application in promoting tissue regeneration, particularly in dental and bone repair. These cells were found to hold significant promise for use in tissue engineering, with consistent evidence supporting their potential in regenerative medicine.
Conclusions: Stem cells derived from dental periapical lesions represent a promising and accessible resource for regenerative therapies. Their capacity for multi-lineage differentiation and successful application in tissue repair underscores their therapeutic potential in regenerative medicine. Further research is needed to optimize their clinical use and explore broader applications in tissue engineering.
Methods: A systematic literature search is conducted using databases including PubMed and Scopus, alongside hand-searching relevant journals. Studies on human dental periapical lesions and their derived stem cells were included, while animal studies, non-dental stem cell sources and teeth with communication to periodontal pockets were excluded. Data extraction focused on stem cell characteristics, differentiation capacity, and regenerative applications. The Cochrane Risk of Bias tool (RoB 2) is to be used to assess the risk of bias, and a narrative synthesis will be performed to summarize the findings.
Results: Stem cells from dental periapical lesions exhibit key stem cell markers and demonstrate strong differentiation potential into osteogenic, chondrogenic, and adipogenic lineages. Several studies report their successful application in promoting tissue regeneration, particularly in dental and bone repair. These cells were found to hold significant promise for use in tissue engineering, with consistent evidence supporting their potential in regenerative medicine.
Conclusions: Stem cells derived from dental periapical lesions represent a promising and accessible resource for regenerative therapies. Their capacity for multi-lineage differentiation and successful application in tissue repair underscores their therapeutic potential in regenerative medicine. Further research is needed to optimize their clinical use and explore broader applications in tissue engineering.