IADR Abstract Archives
Clinico-Histopathological Profile and Prognosis of Oral Squamous Cell Carcinoma : a 6-Year Single-Center Experience
Objectives: The aim of this study is to report the demographic, the clinico-histopathological and prognosis features of oral squamous cell carcinoma (OSCC) diagnosed in a tunisian population in a 6-year period.
Methods: A retrospective cohort study of OSCC patients diagnosed from 2013 to 2018 and treated at the department of Oral and Maxillofacial Surgery of Sahloul University Hospital was conducted. The histopathological reports were reviewed by one experimental anatomopathologist at Farhat Hached Hospital. Descriptive statistics of population and tumor characteristics were analysed. Overall survival rate and survival comparisons were estimated using the Kaplan-Meier method and the log-rank test (p≤0.2).
Results: A total of 190 OSCC was reviewed. Mean age of the patients was 64,8 years-old. Most patients were men (66,3%). Males reported both tobacco and alcohol consumption more frequently than females. Mean size of the tumors was 3 ±1,34 cm. OSCC mostly affected mandibular gingiva, inferior lip, buccal mucosa and lateral border of the tongue. Histological grade of the tumors revealed that 42,8% and 52,4% of the tumors were, respectively, classified as well and moderately-differentiated OSCC. 59,1% of patients had advanced (clinical stage III or IV) OSCC at diagnosis. Non-surgical treatment, advanced stage, lymph node metastasis and extracapsular spread were independently associated with poor prognosis (p≤0.2, Log rank). The mean survival rate at 5 years was 54 months [95%, 103-130,5].
Conclusions: The present study reflects the epidemiological and clinico-histopathological features and overall survival rate at 5 years of OSCC diagnosed in a single Tunisian institution. The data found was mostly in agreement with literature.
Methods: A retrospective cohort study of OSCC patients diagnosed from 2013 to 2018 and treated at the department of Oral and Maxillofacial Surgery of Sahloul University Hospital was conducted. The histopathological reports were reviewed by one experimental anatomopathologist at Farhat Hached Hospital. Descriptive statistics of population and tumor characteristics were analysed. Overall survival rate and survival comparisons were estimated using the Kaplan-Meier method and the log-rank test (p≤0.2).
Results: A total of 190 OSCC was reviewed. Mean age of the patients was 64,8 years-old. Most patients were men (66,3%). Males reported both tobacco and alcohol consumption more frequently than females. Mean size of the tumors was 3 ±1,34 cm. OSCC mostly affected mandibular gingiva, inferior lip, buccal mucosa and lateral border of the tongue. Histological grade of the tumors revealed that 42,8% and 52,4% of the tumors were, respectively, classified as well and moderately-differentiated OSCC. 59,1% of patients had advanced (clinical stage III or IV) OSCC at diagnosis. Non-surgical treatment, advanced stage, lymph node metastasis and extracapsular spread were independently associated with poor prognosis (p≤0.2, Log rank). The mean survival rate at 5 years was 54 months [95%, 103-130,5].
Conclusions: The present study reflects the epidemiological and clinico-histopathological features and overall survival rate at 5 years of OSCC diagnosed in a single Tunisian institution. The data found was mostly in agreement with literature.