Gorlin-Goltz syndrome: a case series of 12 patients
Objectives: To report 12 cases of Gorlin syndrome and discuss through a literature review, the main features of this rare disease.
Methods: This a retrospective study of 12 cases of Gorlin syndrome collected in our department between 1993 and 2016. The clinical, radiological, and histopathological findings and major and minor criteria were described.
Results: The patient group included 6 females and 6 males. Age ranged from 4 to 64 years. Six patients were sporadic cases, and 6 patients had other affected family members. In all our patients, diagnostic criteria were fulfilled. Basal cell carcinomas and jaw cysts were the most frequent clinical features.
Conclusions: The patient cohort illustrates classic and rare disease manifestations. Patient with Gorlin-Goltz syndrome needs a particular multidisciplinary medical and dental approach for management. Patients should be offered genetic counseling and life-long surveillance