Analysis of CRP Levels and Periodontal Status in Type2 Diabetics

Objectives: Periodontitis is one of the oral manifestations in diabetic patient type 2. In diabetic patient, increased levels of CRP resulted in periodontal tissue destruction. CRP is an alpha-globulin protein produced in the liver in the event of increased levels of inflammation. The purpose of this study was to analyze the profile of CRP levels in type 2 DM patients with periodontitis. Methods: This study was an analytical observational study. A selective random sampling was used. The samples were 11 diabetic patient type 2 with periodontitis (test group), and 11 diabetic patients type 2 without periodontitis (control group) from Sultan Agung Islamic Hospital. All subjects were examined using periodontal index, levels of CRP, and oral hygiene index (OHI). Results: The test group showed CRP levels interval between 12 mg/l - 96 mg/l, and periodontal index between 4-6. The control group showed CRP levels interval between 6 mg/l - 12 mg/l without periodontitis.  Mann Whitney’s test showed the CRP levels in the test group were higher than control group (p<0.05). Spearmann-Kendall’s correlation showed the relationship between CRP levels and periodontal index was strong (r=0. 875, p<0.05). The correlation between OHI and periodontal index was also strong (r=0.650, p<0.05). Conclusion: CRP levels in type 2 diabetic patients with periodontitis were higher than the type 2 diabetic patients without periodontitis. There was a strong relationship between levels of CRP and periodontal index and also OHI and periodontal index. Higher CRP levels were associated with an increased periodontal index in type 2 diabetic patients.