Bioactivity of Stichopus Hermanii  to BMP-2 Expression in Repapse Orthodontic

Objective: The aim of this study is to investigate bioactivity of Stichopus hermanii  to BMP-2 (Bone Morphogenetic Protein-2) expression to prevent relapse in orthodontic treatment. Method:  The experiment was held by Post Test Only Group design. Thirty two male Cavia Cobaya were divided into four groups. K(-) group as negative control group (without treatment), K(+) group as positive control group which is given with orthodontic mechanical forces, and the other groups; P1, P2, were given with orthodontic mechanical forces and stichopus hermanii 2.5 % and 3 % respectively. After treatment the rats were sacrificed. BMP-2 expression was examined with immunohistochemistry. Result: This study showed means and SD in K(-), K(+), P1,and P2 were 7.13±2.17; 3.75±1.98; 13.38±2.5 and 21±1.3. BMP-2 expression was significantly differences in group P2 compare to  K(-) and K(+), group P1.  P1 and P2 showed increased BMP-2 expression whether P2 has the best expression. Conclusion: Stichopus hermanii 3 % had the best bioactivity so BMP-2 expression can be increased to prevent relapse in orthodontic.