Anti-erosion and Reminerlization Efficacy of Novel Fluoridated Composite Resin

Objective: The aim of this study was to develop a novel fluoridated dental composite resin (denoted as F-Ka-Compsite) with enabled substantial fluoride release and remineralization efficacy. Methods: Fluorinated kaolinite inorganic fillers were synthesized by the intercalation and incorporated into bis-GMA to form F-Ka-Composite. We determined the fluoride release profile compared to commercial restorative materials, light cured Fuji II Glass Ionomer ® (Fuji II GIC), Estelite® and Beautifil® . We restored tooth cavities in vitro by the above materials for the de- and re-mineralization test in the artificial caries model. The restored specimens were digitized with high-resolution micro-computed tomography (micro-CT) scanning and CTAn 3D reconstruction imaging system. Results: The amount of fluoride release of F-Ka-Compsite (28 ppm) could reach the level as high as Fuji II GIC ® cement (32 ppm), while Estelite® and Beautifil® presented showed much lower level (<5 ppm) after 21 days. The micro-CT 3D data demonstrated that F-Ka-Compsite has certain anti-erosion remineralization effect on the restored tooth compared to Estelite® and Beautifil® (p<0.05). Conclusion: The novel F-Ka-Compsite has a greater potential of initial caries and secondary caries prevention. The kinetic of fluoride release and interaction of the F-Ka-Compsite and enamel should be explored.