Development of a Novel Antibacterial Membrane for Guided Tissue Regeneration

Objective: The aim of the project was to incorporate an antibiotic into barrier membranes suited for use in GTR. Method: Poly ether urethane membranes were fabricated using solvent casting technique. Doxycycline Hyclate, which is used in periodontal therapy due to its antibacterial effect was incorporated into the polyether urethane membrane back bone and grafted onto the surface of the membrane for characterization. Methylene Diphenyl Diisocyanate was grafted onto the surface of the polymer before attaching doxycycline hyclate, and its purpose was to act as a spacer. Different concentrations of the drug were grafted onto the membrane and the best spectrum was used to study the details. Fourier transform infrared (FTIR) and Raman Spectroscopy analysis were done for surface characterization to analyze surface grafted and drug incorporated membranes. Contact angle and surface energy of the membranes were also measured. Results: Results showed that there was interaction of the drug with the membrane as seen on the spectral data, and the peak shifts of FTIR have supported that. Conclusion:Doxycycline hyclate incorporation in membranes is possible and such membranes might enhance GTR efficacy due to antibacterial effects and increased hydrophilicity