Comparison of efficacy of Fluconazole mouthrinse and Clotrimazole mouthpaint in the treatment of oral candidiasis.
Methods:
89 patients were enrolled in the study. 43 patients used Fluconazole mouthrinse (Group A) while 46 patients used Clotrimazole mouthpaint (Group B) for a period of 2 weeks. For Group A patients a suspension of 2 mg/ml of Fluconazole in distilled water was given and each patient was instructed to rinse mouth with 5 ml of the solution for 2-3 minutes and then swallow. Group B patients were treated with Clotrimazole mouthpaint (1%). They were advised to apply the mouth paint to the affected areas thrice daily for two weeks. Patients were recalled after two weeks.
Results:
26 patients in Group A and 22 patients in Group B had total clinical cure. Chi square test was used for comparison of the distribution of all the variables. Both treatment regimens were well tolerated.
Conclusion:
Fluconazole mouthrinse was found to have better efficacy than Clotrimazole mouthpaint in the treatment of Oral Candidiasis. The results of this study can be used as a basis for further studies with larger sample of patients with oral candidiasis to compare the efficacy of fluconazole aqueous mouthrinse with clotrimazole mouth paint.