Background: Oral dryness is often seen as one of oral complication and can lead to the decrease quality of life in elderly people. Several studies have been carried out to find factors that related to this condition, but the results were still inconsistent. Objective: To assess the relationship between age, gender, the numbers of systemic disease and medication, nutritional status and smoking habit with salivary flow rate and xerostomia in elderly patient at Geriatric/Elderly clinic Cipto Mangunkusumo General Hospital, Jakarta Method: This study was an observational cross sectional study. Consecutive sampling method was used to obtain the subjects. One hundred and twenty seven patients who met the inclusion criteria were interviewed with questionnaire about subjective complaint of dry mouth. The body mass index and salivary flow rate were measured. Results: We found that the numbers of systemic disease and medications negatively correlated with both unstimulated (r=-0.336 and -0.228) and stimulated (r=-0.221 and -0.193) salivary flow rate respectively but only unstimulated salivary flow rate showed significant relationship with the numbers of systemic disease (p=0.024) and medications (p=0.012). In addition, there were significant relationships between gender (p=0.045) and the numbers of systemic disease (p=0.011) with xerostomia. Other variables did not show any relationship with unstimulated and stimulated salivary flow rate and xerostomia. Conclusion: In elderly people, the numbers of systemic disease and medication were related to salivary flow rate, while the numbers of systemic disease and gender related to xerostomia. Key words: Age, gender, the amount of systemic disease and medication, nutritional status, smoking habit, salivary flow rate, xerostomia.