In HIV-infected individuals, depletion of CD4+ T-cells is associated with a loss immune function. Salivary immunoglobulin A (IgA), is a useful indicator of mucosal immune function. This immune system component is recognized as an important first-line of defense on oral mucosal surfaces. Objectives: The aim of this study was to investigate possible alterations in salivary IgA levels in HIV-infected patients, and to determine correlation between salivary IgA levels, salivary flow rate (SFR) and CD4 T-cell count. Methods: This cross-sectional study was performed at Pokdisus AIDS Cipto Mangunkusumo Hospital, Jakarta. Whole paraffin-wax-stimulated saliva was collected from 103 HIV-infected patients (age range 20-46 years old) and 30 healthy volunteers as the controls (age range 20-43 years old). Saliva was collected using the spit method. Total salivary IgA in mg/dl was determined by the immunoturbidimetry method using the Behring Turbitimer Analyser. Results: Total salivary IgA levels were 141.55 ± 83.23 mg/dl (HIV group) and 97.24 ± 38.25 mg/dl(control group). The results indicate that total salivary IgA levels were statistically significant higher in HIV-infected patients compared with controls (p = 0.014, Mann Whitney-Test). The stimulated flow rates in the HIV-infected patients and controls were 1.82 ± 0.98 and 1.78 ± 0.79 ml/min. No significant difference was found. (P = 0.794, Mann Whitney-Test).There was a significantly inverse correlation between the salivary flow rate and salivary IgA levels (r = - 0.547, p < 0.001, Spearman's correlation-Test). Salivary IgA and CD4+ T-cell count showed no statistically significant correlation (r = 0.051, p = 0.609, Spearman's correlation-Test). Conclusion: Our study indicates that total salivary IgA levels were significantly higher in the HIV-infected patients compared to control, and salivary IgA level seem not to be related to CD4+ T-cell counts, but there was significant inverse correlation with salivary flow rate.