Objective:To improve a clinician's ability to predict the soft-tissue profile changes of Class III camouflage treatment, and determine if there are any significant differences in profile changes between pseudo-Class III and true Class III patients and between extraction and non-extraction treatment in Class III patients. Method:The pre- and post cephalometric records of 45 Class III female subjects and 21 pseudo-Class III female subjects were digitized and analyzed. Result:Pearson's correlation test revealed that there were correlations between changes of soft-tissue and underlying hard-tissue, then mean ratios were calculated (Sls:A=1.50:1, Ls:Is=0.79:1, Li:Ii=0.56:1, Ils:B=0.19:1, Pg':Pg=0.94:1, Pg':Gn=0.80:1). As multiple regression equations were established, they showed that soft-tissue response was related to the changes in several underlying hard-tissues. For determination of different changes in soft-tissue between groups, ANOVA and Scheffe's test were used. Both maxillary and mandibular incisors of the pseudo-Class III group were brought into normal position through different distances, whereas they were more compensated in the Class III group. Maxillary incisors were proclined in the Class III non-extraction group. In the Class III extraction group, the mandibular incisors were retroclined to compensate for the skeletal discrepancy. The same direction of both upper and lower lips movement to their supporting dentition was observed in different magnitudes in every group. Mann-Whitney test was used to investigate the factors which may affect the response of soft-tissue. It was found that extraction factors possibly affected lower lip response to both maxillary and mandibular incisor movement, whereas, no significant difference in soft-tissue response between pseudo-Class III and Class III groups was found. Conclusion:Since the factors which could affect the soft-tissue profile change were eliminated by sample specification, more accuracy of soft-tissue profile prediction could be expected. In camouflage treatment, the results from extraction seem to be more effect to soft-tissue profile changes than skeletal type.