Objective: The aim of the study was to investigate whether either incisal guidance or interference during protrusion related to temporomandibular disorders (TMDs). Methods: TMDs in this study were defined as joint pain, joint sound and jaw deviation. A total of 104 third and forth year dental students, Prince of Songkla University (74 females and 30 males) were examined and interviewed. Clinical examinations included the presence of incisal guidance and interference during protrusion, and jaw deviation during opening. History of joint and muscle pain, and joint sound were also recorded. The occurrence of the data was presented in percent. The relationships between either incisal guidance or interference during protrusion and joint pain, joint sound, and jaw deviation were tested using Chi-square at p< 0.05. Results: The results showed that 82 % of the samples had incisal guidance while 18 % had not. 56 % of the samples had incisal interference during protrusion while 43 % had not. 34% of the samples had history of joint pain. 65 % of the samples had experienced joint sound. 25 % of the samples has straight jaw opening while 75 % had deviated jaw during opening. The Chi-square showed no association between either incisal guidance or interference and TMDs. Conclusion: This revealed that absence or presence of incisal guidance or interference is not related to TMDs in this group of population.