India has the largest number of working teenagers in the world with the credible estimates ranging from 60-115 millions. These teenagers mostly belong to the low-socio-economic and illiterate group. Hence, they become more vulnerable to the use of different forms of cheap, locally made tobacco and alcohol, which are the high-risk factors for developing precancerous lesions. Objectives: In view of increased prevalence of oral cancer and with predisposition of these working children to various risk factors, this study was undertaken to determine the percentage of precancerous lesion and to curtail the disease in its early stage by triphala, an ayurvedic preparation. Methods: Low resource screening by new method visual inspection with acetic acid was undertaken in 13-19 year working child population. The positive subjects were further investigated by pap smear and biopsy. The confirmed lesions were treated with triphala mouth rinse for nine months. Results: 25% subjects involved with smokeless tobacco, which is quite alarming, have shown a significant number (3.1%) having acetowhite lesions. Histological findings after biopsy at baseline showed hyperkeratinization in 15 (44.1%), hyperkeratinization and acanthosis in 3 (8.8%), Hyperkeratinization and intracellular oedema in 2 (5.9%) cases. Hyperkeratinization and spongiosis, hyperkeratinization, acanthosis and parakeratin plugging, hyperkeratinization, acanthosis and basilar hyperplasia and mild pleomorphism was evident in 1 (2.9%) respectively in each type. The abnormal picture was found in 96.3% and after 9-month post rinse 81.4% of them showed reversal to normal. Linear-by-Linear Association by chi square test showed high statistically significant correlation. (P<0.01) Conclusion: India being a developing country with limited resources needs such screening programs with strict laws on tobacco marketing on large scale. The cost effective, indigenous mouth rinse of triphala may prove to be a key tool in prevention of oral cancer.