IADR Abstract Archives

Efficacy of Intravenous Nicardipine for Deliberate Hypotension

Infusion nicardipine is the standard method using for deliberate hypotension but intermittent bolus technique has been practically used where infusion machine is not available. Objective: To compare the efficacy of an intermittent bolus technique ( IBT) to continuous infusion technique (CIT) of intravenous nicardipine in deliberate hypotension during Le Fort I osteotomy. Methods: Patients were assigned to receive either technique randomly (15 per group).Nicardipine was started when the mucosa was incised to achieve the mean arterial pressure of 55 - 75 mmHg or less than 100 mmHg in the systolic blood pressure. Results: In the IBT group, initial dose of nicardipine was 30 mcg/kg, then 20 mcg /kg every 5 minutes and reduced to 10 mcg/kg every 10 minutes after achieving proposed blood pressure. In the CIT, the initial dose was 5 mcg/kg/min and then titrated to 1-3 mcg/kg/min after achieving the proposed blood pressure. Nicardipine was discontinued after maxillary downfracture and bleeding controlled. Hemodynamic changes, intraoperative blood loss and the quality of surgical field were assessed and recorded. The results showed that total dose of nicardipine in IBT (12.77±3.75mg) was less than the CIT(15.6±4.14 mg) significantly (p< 0.05). However, no difference was observed between the two techniques with respect to time to hypotension (IBT 4.83±4.48 min, CIT 7.17±5.74 min), time to baseline (IBT 87.33±65.84 min, CIT 77.33±63.3 min), intraoperative blood loss (IBT 376.6±127.37 ml, CIT 406.6±94.37 ml) and the quality of surgical field. Conclusion: Intravenous nicardipine intermittent bolus technique is efficacious and can be used to induce deliberate hypotension during Le Fort I osteotomy. This study was supported by Graduate School and Faculty of Dentistry, Prince of Songkla University.


Division: Southeast Asian Division Meeting
Meeting: 2004 Southeast Asian Division Meeting (Koh Samui, Thailand)
Location: Koh Samui, Thailand
Year: 2004
Final Presentation ID: 174
Abstract Category|Abstract Category(s): Scientific Groups
Authors
  • Klabkly, Praweena  ( Prince of Songkla University, Hat Yai, Songkhla, N/A, Thailand )
  • Pripatnanont, Prisana  ( Prince of Songkla University, Songkhla, N/A, Thailand )
  • Vongvatcharanont, Surapong  ( Prince of Songkla University, Hat Yai, Songkhla, N/A, Thailand )
  • Kittidumkerng, Winai  ( Prince of Songkla University, Hat Yai, Songkhla, N/A, Thailand )
  • SESSION INFORMATION
    Oral Session
    Oral & Maxillofacial Surgery
    09/05/2004