IADR Abstract Archives
Triglyceride glucose index and severe periodontitis: role of blood pressure
Objectives: Globally, 1.1 billion people are affected by severe periodontitis, an ageing-associated inflammatory condition that destroys supporting tissues of teeth resulting in tooth loss and negatively impacting quality of life. Evidence suggests that triglyceride-glucose index, a surrogate marker for insulin resistance, may be associated with periodontitis. However, mechanistic pathways underlying this association are still unclear, especially in severe cases. Therefore, this study assessed the association between triglyceride glucose index (Tyg index) and severe periodontitis and investigated the role of blood pressure as a potential mediator in the association.
Methods: Data was obtained from 7,679 US adults with complete periodontal examinations, participating in the 2011-2014 National Health and Nutrition Examination Survey cycles. Participants were classified based on attachment loss and probing pocket depth into mild, moderate, severe, and no periodontitis, with the main outcome further dichotomized into moderate/severe periodontitis and mild/no periodontitis. The main exposure was the TyG index and systolic blood pressure (SBP) was the mediator tested in the pathway analysis using g-computation. Age, gender, race, poverty-income ratio, smoking status, presence of obesity, dyslipidaemia, and diabetes were included as potential confounders.
Results: Findings showed that 44.05% of the US adults, aged 30 years and above, were affected by moderate/severe periodontitis. Univariate analysis demonstrated a significant association between moderate/severe periodontitis and TyG index [odds ratio (OR), 95% confidence interval (CI) =1.54, 1.17 - 2.04)]. Stratified analysis showed the association to be statistically significant in obese and dyslipidaemia individuals (both p<0.05). After adjusting for potential confounders, SBP was shown to mediate the association of TyG index and moderate/severe periodontitis, with 44% of the proportion of total effect mediated. A direct effect of the TyG index on moderate/severe periodontitis was also noted.
Conclusions: Triglyceride-glucose index is linearly associated with increased odds of moderate/severe periodontitis, with the association partially mediated by underlying SBP levels.
Methods: Data was obtained from 7,679 US adults with complete periodontal examinations, participating in the 2011-2014 National Health and Nutrition Examination Survey cycles. Participants were classified based on attachment loss and probing pocket depth into mild, moderate, severe, and no periodontitis, with the main outcome further dichotomized into moderate/severe periodontitis and mild/no periodontitis. The main exposure was the TyG index and systolic blood pressure (SBP) was the mediator tested in the pathway analysis using g-computation. Age, gender, race, poverty-income ratio, smoking status, presence of obesity, dyslipidaemia, and diabetes were included as potential confounders.
Results: Findings showed that 44.05% of the US adults, aged 30 years and above, were affected by moderate/severe periodontitis. Univariate analysis demonstrated a significant association between moderate/severe periodontitis and TyG index [odds ratio (OR), 95% confidence interval (CI) =1.54, 1.17 - 2.04)]. Stratified analysis showed the association to be statistically significant in obese and dyslipidaemia individuals (both p<0.05). After adjusting for potential confounders, SBP was shown to mediate the association of TyG index and moderate/severe periodontitis, with 44% of the proportion of total effect mediated. A direct effect of the TyG index on moderate/severe periodontitis was also noted.
Conclusions: Triglyceride-glucose index is linearly associated with increased odds of moderate/severe periodontitis, with the association partially mediated by underlying SBP levels.