IADR Abstract Archives
Impact of Tocopherol and Pentoxifylline before Tooth Extraction on Osteoradionecrosis
Objectives: Osteoradionecrosis of the jaws (ORN) is a rare but severe condition that significantly impacts the quality of life in patients with a history of head and neck irradiation. Currently, there is no established treatment regimen that shows promising results. The use of Pentoxifylline in combination with Tocopherol has demonstrated effectiveness in reducing radiation fibrosis after breast irradiation. However, its potential for preventing ORN prior to tooth extraction requires further investigation.
Methods: Retrospective data was collected from computer-based medical records between 2017 and 2020 at a cancer center in Thailand. A total of 43 head and neck irradiated patients underwent tooth extraction, resulting in the extraction of 110 teeth. Prior to and following tooth extraction, all patients were prescribed pentoxifylline 400 mg twice a day and tocopherol 1000 IU per day. Data on primary tumor diagnosis, staging and location, diagnosis of the extracted tooth, and any drug complications were recorded.
Results: Among the tooth extractions, 6 sites in 3 patients were diagnosed with ORN, resulting in a prevalence rate of 5.4% at the tooth level and 6.9% at the patient level. Although the odds of ORN occurrence were 3.67 times higher in the mandible compared to the maxilla, this association was not statistically significant (95% CI: 0.4136 to 32.5024). No statistically significant associations were found among the factors studied, and no drugs complication was reported.
Conclusions: The administration of Pentoxifylline and Tocopherol did not demonstrate a reduction in the prevalence of ORN compared to rates reported in previous evidence-based studies. However, it should be noted that the number of patients in this study was limited. Further studies with larger sample sizes or experimental designs are necessary to fully elucidate the efficacy of these drugs in preventing ORN.
Methods: Retrospective data was collected from computer-based medical records between 2017 and 2020 at a cancer center in Thailand. A total of 43 head and neck irradiated patients underwent tooth extraction, resulting in the extraction of 110 teeth. Prior to and following tooth extraction, all patients were prescribed pentoxifylline 400 mg twice a day and tocopherol 1000 IU per day. Data on primary tumor diagnosis, staging and location, diagnosis of the extracted tooth, and any drug complications were recorded.
Results: Among the tooth extractions, 6 sites in 3 patients were diagnosed with ORN, resulting in a prevalence rate of 5.4% at the tooth level and 6.9% at the patient level. Although the odds of ORN occurrence were 3.67 times higher in the mandible compared to the maxilla, this association was not statistically significant (95% CI: 0.4136 to 32.5024). No statistically significant associations were found among the factors studied, and no drugs complication was reported.
Conclusions: The administration of Pentoxifylline and Tocopherol did not demonstrate a reduction in the prevalence of ORN compared to rates reported in previous evidence-based studies. However, it should be noted that the number of patients in this study was limited. Further studies with larger sample sizes or experimental designs are necessary to fully elucidate the efficacy of these drugs in preventing ORN.