IADR Abstract Archives
Periodontal health and APRIL/BAFF salivary levels in rheumatoid arthitis patients
Objectives: Periodontitis (PD) and rheumatoid arthritis (RA) are chronic inflammatory diseases characterized by bone and tissue destruction. These two conditions share several clinical and pathological features as well as risk factors. This study aimed to investigate the periodontal health and the levels of TNF-superfamily members, APRIL and BAFF, in saliva samples of RA patients.
Methods: The patients with established RA (n=39), predominantly women (92.3%) with a mean age of 63.4±10.2 years, were recruited from Karolinska University Hospital (Stockholm). All participants underwent a full mouth dental examination and collection of stimulated saliva. Periodontal parameters include plaque index (PI), bleeding on probing (BoP), probing pocket depth (PPD) and number of missing teeth. Periodontal diagnosis followed the new classification of Caton, et al. 2018. The levels of APRIL and BAFF (pg/ml) were analyzed using immunoassay kits.
Results: Among the participants, 31% (n=12) were diagnosed with PD stage 2; 54% (n=21) were diagnosed with PD stage 3; and 15% (n=6) were diagnosed with PD stage 4.
The periodontal parameters for the groups with PD stage 2, 3 and 4 were as follows. For PI 57.1%, 48.0%, and 37.3%; for BoP 27.5%, 31.8%, and 50.6%, for PPD 4-5 mm 2,6%, 8.1% and 10.9; for missing teeth 1.3, 2.2 and 9.3, respectively.
Mean salivary levels of APRIL and BAFF were measured in three PD groups (stage 2, 3, and 4). PD group with stage 4 exhibited significantly (p <0.05) higher levels of APRIL as compared to group 2 and 3 (42882, 53048, and 301645, respectively). Additionally, BAFF levels were significantly higher (p <0.05) in group 4 as compared to group 3 (4612 and 2971, respectively).
Conclusions: In this cross-sectional study, high prevalence of PD was observed in patients with RA. The salivary levels of TNF-superfamily members, APRIL and BAFF, increased with stages of PD. Further research with larger sample size is needed to elucidate the role of APRIL and BAFF in the pathogenesis and progression of PD in patients with RA.
Methods: The patients with established RA (n=39), predominantly women (92.3%) with a mean age of 63.4±10.2 years, were recruited from Karolinska University Hospital (Stockholm). All participants underwent a full mouth dental examination and collection of stimulated saliva. Periodontal parameters include plaque index (PI), bleeding on probing (BoP), probing pocket depth (PPD) and number of missing teeth. Periodontal diagnosis followed the new classification of Caton, et al. 2018. The levels of APRIL and BAFF (pg/ml) were analyzed using immunoassay kits.
Results: Among the participants, 31% (n=12) were diagnosed with PD stage 2; 54% (n=21) were diagnosed with PD stage 3; and 15% (n=6) were diagnosed with PD stage 4.
The periodontal parameters for the groups with PD stage 2, 3 and 4 were as follows. For PI 57.1%, 48.0%, and 37.3%; for BoP 27.5%, 31.8%, and 50.6%, for PPD 4-5 mm 2,6%, 8.1% and 10.9; for missing teeth 1.3, 2.2 and 9.3, respectively.
Mean salivary levels of APRIL and BAFF were measured in three PD groups (stage 2, 3, and 4). PD group with stage 4 exhibited significantly (p <0.05) higher levels of APRIL as compared to group 2 and 3 (42882, 53048, and 301645, respectively). Additionally, BAFF levels were significantly higher (p <0.05) in group 4 as compared to group 3 (4612 and 2971, respectively).
Conclusions: In this cross-sectional study, high prevalence of PD was observed in patients with RA. The salivary levels of TNF-superfamily members, APRIL and BAFF, increased with stages of PD. Further research with larger sample size is needed to elucidate the role of APRIL and BAFF in the pathogenesis and progression of PD in patients with RA.