IADR Abstract Archives
Platelet-rich Plasma Therapy in Oral Lichen Planus: A Systematic Review
Objectives: Oral lichen planus (OLP) is regarded as an oral potentially malignant disorder. Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) have been suggested as alternative treatment modalities for managing OLP. The aim of this systematic review is to evaluate the efficacy of intralesional PRP/PRF injections compared to intralesional corticosteroid injections in the treatment of OLP.
Methods: This study was registered on PROSPERO (CRD42023389196). Electronic databases including MEDLINE via PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), Scopus, ClinicalTrials.gov, World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) Search portal, EBSCO Opendissertion and grey literature (Opengrey.eu) up to March 16, 2023. Randomized controlled trials which compared the clinical efficacy of intralesional PRP/PRF injection and intralesional corticosteroids injections in the management of OLP were included in this review. Two reviewers independently selected eligible articles, collected data, and qualitatively evaluated each included study.
Results: Nine studies were eligible for assessment. Four out of nine were excluded due to no control groups. Five remaining articles were included and extracted for data. A total number of 85 participants diagnosed with OLP were included. Three studies used PRF and two studies used PRP as intervention, while the control were triamcinolone acetonide in four studies and methylprednisolone in one study. Clinical parameters were reported as REU score, lesion size, and Thongprasom’s score. After treatment, PRP/PRF significantly reduced clinical parameters from baseline, similarly to the control group. Additionally, pain/burning sensation significantly reduced from baseline in both groups.
Conclusions: The evidence suggested that intralesional PRP/PRF injections can reduce pain and clinical lesion scores comparable to the conventional intralesional corticosteroid injection. Therefore, PRP/PRF could be used as an effective alternative therapy in patients with OLP, especially for those with refractory lesions.
Methods: This study was registered on PROSPERO (CRD42023389196). Electronic databases including MEDLINE via PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), Scopus, ClinicalTrials.gov, World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) Search portal, EBSCO Opendissertion and grey literature (Opengrey.eu) up to March 16, 2023. Randomized controlled trials which compared the clinical efficacy of intralesional PRP/PRF injection and intralesional corticosteroids injections in the management of OLP were included in this review. Two reviewers independently selected eligible articles, collected data, and qualitatively evaluated each included study.
Results: Nine studies were eligible for assessment. Four out of nine were excluded due to no control groups. Five remaining articles were included and extracted for data. A total number of 85 participants diagnosed with OLP were included. Three studies used PRF and two studies used PRP as intervention, while the control were triamcinolone acetonide in four studies and methylprednisolone in one study. Clinical parameters were reported as REU score, lesion size, and Thongprasom’s score. After treatment, PRP/PRF significantly reduced clinical parameters from baseline, similarly to the control group. Additionally, pain/burning sensation significantly reduced from baseline in both groups.
Conclusions: The evidence suggested that intralesional PRP/PRF injections can reduce pain and clinical lesion scores comparable to the conventional intralesional corticosteroid injection. Therefore, PRP/PRF could be used as an effective alternative therapy in patients with OLP, especially for those with refractory lesions.