IADR Abstract Archives
Oral Biofluid Biomarkers associated with Peri-Implantitis: A Systematic Review
Objectives: The objective of this systematic review is to explore current studies on salivary and peri-implant sulcular fluid (PISF) biomarkers for peri-implantitis. The aim is to identify reliable biomarkers that can be used for the early detection and monitoring of peri-implantitis, which is crucial for timely intervention and improved treatment outcomes.
Methods: A systematic search was conducted on two databases, PubMed and Scopus, to identify relevant studies published until January 2023. The search aimed to identify articles that investigated salivary and PISF biomarkers in relation to peri-implantitis. A total of 90 articles were included in this review, and data extraction and analysis were performed on the selected articles.
Results: The review reveals that several biomarkers in salivary and PISF samples have been investigated for their association with peri-implantitis. These biomarkers fall into various categories, including inflammatory markers, matrix metalloproteinases, bone loss markers, and microbial markers. Elevated levels of pro-inflammatory cytokines, such as interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and matrix metalloproteinases, were consistently found in both saliva and PISF samples and were associated with peri-implantitis. Additionally, osteoprotegerin (OPG) and soluble receptor activator of nuclear factor-kappa B ligand (sRANKL) showed significant increases specifically in PISF samples.
Conclusions: This systematic review provides insights into the current research on salivary and PISF biomarkers for peri-implantitis. The identified biomarkers hold promise as noninvasive diagnostic tools for early detection, monitoring, and personalized management of peri-implantitis. Future studies should focus on establishing standardized protocols and conducting well-designed clinical trials to validate the diagnostic accuracy and clinical relevance of these biomarkers.
Methods: A systematic search was conducted on two databases, PubMed and Scopus, to identify relevant studies published until January 2023. The search aimed to identify articles that investigated salivary and PISF biomarkers in relation to peri-implantitis. A total of 90 articles were included in this review, and data extraction and analysis were performed on the selected articles.
Results: The review reveals that several biomarkers in salivary and PISF samples have been investigated for their association with peri-implantitis. These biomarkers fall into various categories, including inflammatory markers, matrix metalloproteinases, bone loss markers, and microbial markers. Elevated levels of pro-inflammatory cytokines, such as interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and matrix metalloproteinases, were consistently found in both saliva and PISF samples and were associated with peri-implantitis. Additionally, osteoprotegerin (OPG) and soluble receptor activator of nuclear factor-kappa B ligand (sRANKL) showed significant increases specifically in PISF samples.
Conclusions: This systematic review provides insights into the current research on salivary and PISF biomarkers for peri-implantitis. The identified biomarkers hold promise as noninvasive diagnostic tools for early detection, monitoring, and personalized management of peri-implantitis. Future studies should focus on establishing standardized protocols and conducting well-designed clinical trials to validate the diagnostic accuracy and clinical relevance of these biomarkers.