IADR Abstract Archives
Association between PISA and Elevated hs-CRP Levels in Thai Adults
Objectives: Extensive research has explored systemic inflammation induced by periodontitis, but inconsistent results across studies due to varying periodontitis case definitions have limited conclusive findings. The novel Periodontal Inflamed Surface Area (PISA) parameter offers a promising measure of periodontal inflammation. However, its relationship with systemic markers remains understudied. This cross-sectional study aimed to investigate the association between PISA and high-sensitivity C-reactive protein (hs-CRP) levels in Thai adults.
Methods: Health questionnaires and physical examinations were conducted on employees of the Electricity Generating Authority of Thailand (EGAT). The hs-CRP was measured by immunoassays from blood samples. Participants with hs-CRP levels exceeding 3 mg/L were categorized into the high hs-CRP group. The PISA was computed using comprehensive periodontal parameters, including measurements of gingival recession, clinical attachment level, and bleeding on probing. The periodontal status was categorized into three distinct groups based on quartiles of PISA value: no/mild (Q1), moderate (Q2,3), and severe periodontitis (Q4). The Kruskal-Wallis test was employed to examine the variations in hs-CRP levels among the three PISA groups. Then, the association between periodontitis and high hs-CRP levels was estimated using the chi-square test.
Results: Of the 2,643 participants aged 34-74 years, the mean hs-CRP level was 1.69±1.74 mg/L, with 16.3% (n=430) having hs-CRP levels above 3 mg/L. Our findings revealed a dose-response relationship between the severity of periodontitis and hs-CRP levels, with participants diagnosed with severe periodontitis exhibiting significantly higher hs-CRP levels compared to those with no/mild periodontitis. Moreover, the presence of elevated hs-CRP levels was significantly associated with the severity of periodontitis (p = 0.025).
Conclusions: PISA, which serves as a representation of periodontal inflammation, showed a noteworthy correlation with increased hs-CRP levels among Thai adults.
Methods: Health questionnaires and physical examinations were conducted on employees of the Electricity Generating Authority of Thailand (EGAT). The hs-CRP was measured by immunoassays from blood samples. Participants with hs-CRP levels exceeding 3 mg/L were categorized into the high hs-CRP group. The PISA was computed using comprehensive periodontal parameters, including measurements of gingival recession, clinical attachment level, and bleeding on probing. The periodontal status was categorized into three distinct groups based on quartiles of PISA value: no/mild (Q1), moderate (Q2,3), and severe periodontitis (Q4). The Kruskal-Wallis test was employed to examine the variations in hs-CRP levels among the three PISA groups. Then, the association between periodontitis and high hs-CRP levels was estimated using the chi-square test.
Results: Of the 2,643 participants aged 34-74 years, the mean hs-CRP level was 1.69±1.74 mg/L, with 16.3% (n=430) having hs-CRP levels above 3 mg/L. Our findings revealed a dose-response relationship between the severity of periodontitis and hs-CRP levels, with participants diagnosed with severe periodontitis exhibiting significantly higher hs-CRP levels compared to those with no/mild periodontitis. Moreover, the presence of elevated hs-CRP levels was significantly associated with the severity of periodontitis (p = 0.025).
Conclusions: PISA, which serves as a representation of periodontal inflammation, showed a noteworthy correlation with increased hs-CRP levels among Thai adults.