IADR Abstract Archives
Increasing of HPV Infection in the Oral Cavity Significantly Rising the Risk of OSCC: a Meta-Analysis Research
Objectives: The increasing of Oral Squamous Cell Carcinoma (OSCC) among people without any classical tobacco and alcohol exposure tempting us there are other risk factors. Human Papillomavirus (HPV) infection has been established as an etiologic factor of cervical and anogenital malignancies but has not been proven in the oral cavity. Along with the increasing of deviant sexual behavior – as also found in developing countries - the virus can be transmitted through direct contact from the genital area to the oral cavity. Does HPV also promote squamous cells carcinogenesis in the oral cavity? The objective of this study, therefore, is to evaluate the association between them, to seek whether this virus also promotes OSCC carcinogenesis in the oral cavity.
Methods: This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). The search strategy used Harzing Publish or Perish software to find studies at Scopus, Pubmed, and Google Scholar databases. Publication limited from 2016 until 2021, case-control research, full paper open access, used Bahasa Indonesia and English. The eligibility of the study was assessed using Newcastle-Ottawa Quality Assessment Scale (NOS). The data was then analyzed using review manager RevMan 5.4.1.
Results: Searches performed through the databases retrieved 1120 articles, after eliminating duplication, screening inclusion, and exclusion criteria only 5 articles remained. Publication of case-control research is very limited. Currently, we do the ongoing study that involves more data by expanding the year of publication, not only open access full paper and database sources. This is only a preliminary report. Quality assessment scale for each article medium to high category. The data was homogeneous with p-value less than 0,05 (p < 0.00001). The Risk ratio (RR) for case OSCC with HPV (+) is 4.63. It means that HPV infection can increase the risk of OSCC by 4.63 times.
Conclusions: The HPV infection was significantly associated with OSCC.
Methods: This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). The search strategy used Harzing Publish or Perish software to find studies at Scopus, Pubmed, and Google Scholar databases. Publication limited from 2016 until 2021, case-control research, full paper open access, used Bahasa Indonesia and English. The eligibility of the study was assessed using Newcastle-Ottawa Quality Assessment Scale (NOS). The data was then analyzed using review manager RevMan 5.4.1.
Results: Searches performed through the databases retrieved 1120 articles, after eliminating duplication, screening inclusion, and exclusion criteria only 5 articles remained. Publication of case-control research is very limited. Currently, we do the ongoing study that involves more data by expanding the year of publication, not only open access full paper and database sources. This is only a preliminary report. Quality assessment scale for each article medium to high category. The data was homogeneous with p-value less than 0,05 (p < 0.00001). The Risk ratio (RR) for case OSCC with HPV (+) is 4.63. It means that HPV infection can increase the risk of OSCC by 4.63 times.
Conclusions: The HPV infection was significantly associated with OSCC.