IADR Abstract Archives
Relationship Between Chronic Periodontitis and Inflammatory Cytokines in Patients Undergoing Maintenance Hemodialysis
Objectives: To investigate the correlation between serum and gingival crevicular fluid (GCF) levels of inflammatory cytokines and the association with periodontal parameters in patients undergoing maintenance hemodialysis (MHD).
Methods: Patients who were undergoing MHD were enrolled as the HD group. Healthy individuals who underwent oral examination were selected as the control group. All participants underwent a full-mouth periodontal evaluation, and the levels of eight inflammatory cytokines, including IL-1β, IL-17, IL-6, IL-8, and TNF-α, MCP-1, MMP-8, and CRP, in the GCF and serum were measured.
Results:
A total of 63 MHD patients and 75 healthy persons were included. The prevalence of moderate/severe periodontitis was significantly higher in the HD group than in the control group (88.9 vs. 66.7%, P<0.05). The levels of GCF and serum C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1), and matrix metalloproteinase-8 (MMP-8) were higher in patients in the HD group with moderate/severe periodontitis than in the control group. The GCF and serum CRP levels were positively correlated with the periodontal clinical parameters. Serum CRP, MCP-1, TNF-α, and MMP-8 levels were positively correlated with the GCF CRP levels.
Conclusions: Periodontitis was more prevalent among patients undergoing MHD than among healthy controls, and CRP may contribute to the association between End-stage renal disease (ESRD) and periodontitis.
Methods: Patients who were undergoing MHD were enrolled as the HD group. Healthy individuals who underwent oral examination were selected as the control group. All participants underwent a full-mouth periodontal evaluation, and the levels of eight inflammatory cytokines, including IL-1β, IL-17, IL-6, IL-8, and TNF-α, MCP-1, MMP-8, and CRP, in the GCF and serum were measured.
Results:
A total of 63 MHD patients and 75 healthy persons were included. The prevalence of moderate/severe periodontitis was significantly higher in the HD group than in the control group (88.9 vs. 66.7%, P<0.05). The levels of GCF and serum C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1), and matrix metalloproteinase-8 (MMP-8) were higher in patients in the HD group with moderate/severe periodontitis than in the control group. The GCF and serum CRP levels were positively correlated with the periodontal clinical parameters. Serum CRP, MCP-1, TNF-α, and MMP-8 levels were positively correlated with the GCF CRP levels.
Conclusions: Periodontitis was more prevalent among patients undergoing MHD than among healthy controls, and CRP may contribute to the association between End-stage renal disease (ESRD) and periodontitis.