IADR Abstract Archives

Clinical Trial to Study the Effect of Medicated Toothpaste on Oral Health

Objectives: The preventive measures and maintenance of oral hygiene are of a priority since the Global Burden of Disease (GBD 2015) study estimates, 3.5 billion people worldwide live with dental conditions, including; untreated dental caries, periodontal disease, and tooth loss. Among various oral hygiene methods, tooth brushing with herbal toothpaste plays a major role in maintaining oral health. We aimed to study the 6-month follow-up and oral health outcomes of medicated toothpaste.
Methods: This active controlled trial was conducted at A B Shetty Memorial Institute of Dental Sciences, Deralakatte, Mangaluru, Karnataka, India. 280 participants aged between 25-50 years, fulfilling the inclusion criteria were recruited in this study. 5mL of saliva was collected and evaluated for total antioxidant capacity (TAC), malondialdehyde (MDA), and vitamin C level for 6-months at 5 intervals.
Results: Participants were recruited from July to October 2020, and allocated into 3 medicated and a control group. The percentage rise in salivary TAC, and vitamin C levels in caries free group of group I, II and III was 174.4 and 42.1, 134.1 and 72.8, 64.1 and 63.1. The percentage of MDA levels in caries free group of group I, II and III was decreased by 57.9, 52.0 and 44.8. The percentage rise in salivary TAC, and vitamin C levels in caries active group of group I, II and III was 137.0 and 45.2, 108.1 and 46.2, 34.4 and 54.1. The percentage decrease in MDA levels of caries active group of group I, II and III was 57.3, 37.6 and 28.6 respectively.
Conclusions: The usage of medicated toothpaste found to reduce the oxidative stress in the oral cavity, thus it helps in enhancing the overall oral health by improving the antioxidant defence system of saliva.

2021 South East Asian Division Meeting (Hong Kong)
Hong Kong
2021
094
Cariology Research-Clinical & Epidemiological Studies
  • Hegde, Mithra  ( A B Shetty Memorial Institute of Dental Sciences , Mangaluru , Karnataka , India )
  • Shetty, Dr  ( A B Shetty Memorial Institute of Dental Sciences , Mangaluru , Karnataka , India )
  • Hegde, Dr  ( A B Shetty Memorial Institute of Dental Sciences , Mangaluru , Karnataka , India )
  • NONE
    Dabur India Ltd.
    Poster Session
    Behavioral, epidemiologic and health services research II
    Thursday, 12/09/2021 , 12:00PM - 01:00PM