IADR Abstract Archives
Genetic Polymorphism in Drug Induced Gingival Enlargements – a Systematic Review
Objectives: Gingival enlargement is a known complication to several important group of drugs. However, not everyone who take these drugs manifest this side effect. The reason behind this discrepancy is yet unknown. Therefore the objective of this review was to investigate the role of genetic polymorphism in the manifestation of drug induced gingival enlargements (DIGE).
Methods: We performed an English language literature search of Medline, Embase and Web of Science databases, using specific keywords as appropriate, to identify case reports and trials that investigated the presence or absence of genetic polymorphisms in patients with DIGE. Literature published until August 2021 were only included. Thirty two studies satisfied all inclusion criteria, and were divided into four groups based on the drug that caused the DIGE. The genes studied, and the mutations identified, were noted, tabulated and analyzed.
Results: A variety of genetic polymorphisms have been identified in patients with DIGE. Mutations in ABCB1, TGF-B1, CYP2C9, and MDR1 seem to be frequently associated with DIGE.
Conclusions: Studies on the role of genetic mutations in DIGE might help clarify the pathogenesis behind this complication that seems to affect only some patients, and may help in better treatment planning.
Methods: We performed an English language literature search of Medline, Embase and Web of Science databases, using specific keywords as appropriate, to identify case reports and trials that investigated the presence or absence of genetic polymorphisms in patients with DIGE. Literature published until August 2021 were only included. Thirty two studies satisfied all inclusion criteria, and were divided into four groups based on the drug that caused the DIGE. The genes studied, and the mutations identified, were noted, tabulated and analyzed.
Results: A variety of genetic polymorphisms have been identified in patients with DIGE. Mutations in ABCB1, TGF-B1, CYP2C9, and MDR1 seem to be frequently associated with DIGE.
Conclusions: Studies on the role of genetic mutations in DIGE might help clarify the pathogenesis behind this complication that seems to affect only some patients, and may help in better treatment planning.