IADR Abstract Archives
The Salivary and Tissue Expression of TNF-α in Recurrent Aphthous Stomatitis
Objectives: Recurrent aphthous stomatitis (RAS) is an oral mucosal inflammation with ulceration as a clinical manifestation and has relation with the increase of TNF-α expression. The purpose of this study is to systematically analyze and assess the level of TNF-α expression in salivary and tissue in patients with RAS.
Methods: A comprehensive search of PubMed, Scopus, Web of Science databases, and Embase was conducted in January 2020. The focused question was ‘Does the RAS patient express a different level of TNF-α compared to a healthy person?’. The inclusion criteria were observational studies that assessed the level of salivary TNF-α and or tissue expression of TNF-α. Studies without control groups, case series, case reports, experimental studies, letter to editors, reviews, were excluded.
Results: Three studies reported the tissue expression of TNF-α in 110 RAS patients and 83 healthy patients with mRNA extraction method (n=2) and IHC method (n=1). Furthermore, six studies reported the salivary TNF-α level in 174 RAS patients and 151 healthy patients with Elisa method. All studies reveal that the level of TNF-α expression in salivary and tissue are higher in RAS patients than in healthy patients with significant differences.
Conclusions: Available data indicates that TNF-α has a role in the pathogenesis of RAS. The increase of TNF-α is very important and able to be used for designing preventative strategies and proper treatment could be performed.
Methods: A comprehensive search of PubMed, Scopus, Web of Science databases, and Embase was conducted in January 2020. The focused question was ‘Does the RAS patient express a different level of TNF-α compared to a healthy person?’. The inclusion criteria were observational studies that assessed the level of salivary TNF-α and or tissue expression of TNF-α. Studies without control groups, case series, case reports, experimental studies, letter to editors, reviews, were excluded.
Results: Three studies reported the tissue expression of TNF-α in 110 RAS patients and 83 healthy patients with mRNA extraction method (n=2) and IHC method (n=1). Furthermore, six studies reported the salivary TNF-α level in 174 RAS patients and 151 healthy patients with Elisa method. All studies reveal that the level of TNF-α expression in salivary and tissue are higher in RAS patients than in healthy patients with significant differences.
Conclusions: Available data indicates that TNF-α has a role in the pathogenesis of RAS. The increase of TNF-α is very important and able to be used for designing preventative strategies and proper treatment could be performed.