IADR Abstract Archives
Associations of Antibody Levels to Porphyromonas Gingivalis and Atrial Fibrillation
Objectives: The present study aimed to examine the association between periodontal condition based on the plasma antibody levels to periodontopathic bacteria and a history of atrial fibrillation (AF).
Methods: A cross-sectional study was conducted on 1,740 participants (1,199 men and 541 women) aged 60–79 years using the baseline health survey data in the Uonuma region of Japan from 2012 to 2014. Data were collected from medical examinations, self-administered questionnaires that enquired about a history of AF, and plasma IgG antibody levels to Porphyromonas gingivalis gingipain. A history of AF (0: absence, 1: presence) was used as a dependent variable while antibody levels (0: ≤third quartile, 1: >third quartile) and a history of angina pectoris were considered independent variables. Age and sex were used as covariates. Multivariate logistic regression analysis was conducted to determine the association between antibody levels to P. gingivalis and a history of AF.
Results: Among 1,740 participants, 39 (2.2%) had AF. Participants with higher antibody levels to P. gingivalis showed a significantly higher prevalence of AF than those with lower antibody levels (4.1% vs. 1.6%; p < 0.05). Multivariate logistic regression analysis showed that participants with higher antibody levels to P. gingivalis had an approximately 3-fold higher odds of having AF (OR = 2.71; 95% CI = 1.42–5.14).
Conclusions: A correlation was observed between antibody levels to P. gingivalis and a history of AF in Japanese adults aged 60–79 years. These results may suggest that periodontal condition contributes to AF onset.
Methods: A cross-sectional study was conducted on 1,740 participants (1,199 men and 541 women) aged 60–79 years using the baseline health survey data in the Uonuma region of Japan from 2012 to 2014. Data were collected from medical examinations, self-administered questionnaires that enquired about a history of AF, and plasma IgG antibody levels to Porphyromonas gingivalis gingipain. A history of AF (0: absence, 1: presence) was used as a dependent variable while antibody levels (0: ≤third quartile, 1: >third quartile) and a history of angina pectoris were considered independent variables. Age and sex were used as covariates. Multivariate logistic regression analysis was conducted to determine the association between antibody levels to P. gingivalis and a history of AF.
Results: Among 1,740 participants, 39 (2.2%) had AF. Participants with higher antibody levels to P. gingivalis showed a significantly higher prevalence of AF than those with lower antibody levels (4.1% vs. 1.6%; p < 0.05). Multivariate logistic regression analysis showed that participants with higher antibody levels to P. gingivalis had an approximately 3-fold higher odds of having AF (OR = 2.71; 95% CI = 1.42–5.14).
Conclusions: A correlation was observed between antibody levels to P. gingivalis and a history of AF in Japanese adults aged 60–79 years. These results may suggest that periodontal condition contributes to AF onset.