IADR Abstract Archives
Caries Arrest With Silver Nitrate and Sodium Fluoride Containing FTCP
Objectives: The aim of this double-blind, parallel-design, randomised controlled trial is to compare the effectiveness of two fluoride application protocols in arresting dentine caries of primary dentition.
Methods: Children aged three with at least one tooth surface with active dentine caries were recruited and randomly allocated into two treatment groups. Children in Group A received a semi-annual application of a 25% silver nitrate (AgNO3) solution followed by a 5% sodium fluoride (NaF) varnish on the carious tooth surfaces. Children in Group B received a semi-annual application of a 25% AgNO3 solution followed by a 5% NaF varnish containing functionalized tricalcium phosphate (fTCP). Carious tooth surfaces that were hard by probing were classified as arrested. Chi-square test, t-test, intention-to-treat analysis, and hierarchical generalized linear model were undertaken.
Results: A total of 408 children with 1,831 tooth surfaces with active dentine caries were recruited at baseline. No significant differences were found between two treatment groups at baseline. At the 24-month evaluation, 356 children (87%) with 1,607 tooth surfaces (88%) were examined. No difference was found in dropout rates between groups. The arrest rates at the tooth-surface level were 42% in Group A (without fTCP) and 57% in Group B (with fTCP) (p<0.001). Results of the hierarchical generalized linear model showed that active carious tooth surfaces treated in Group B (with fTCP) had a higher chance of being arrested than those treated in Group A (without fTCP) (OR=1.91; CI:1.01, 3.60, p=0.046). In addition, tooth-surface type, tooth location, presence of dental plaque, and monthly family income were related to caries arrest rate (p<0.05).
Conclusions: Semi-annual application of a 25% AgNO3 solution followed by a 5% NaF varnish with fTCP is more effective in arresting dentine caries of primary dentition than that of a 25% AgNO3 solution followed by a 5% NaF varnish without fTCP (ClinicalTrial.gov: NCT03423797).
Methods: Children aged three with at least one tooth surface with active dentine caries were recruited and randomly allocated into two treatment groups. Children in Group A received a semi-annual application of a 25% silver nitrate (AgNO3) solution followed by a 5% sodium fluoride (NaF) varnish on the carious tooth surfaces. Children in Group B received a semi-annual application of a 25% AgNO3 solution followed by a 5% NaF varnish containing functionalized tricalcium phosphate (fTCP). Carious tooth surfaces that were hard by probing were classified as arrested. Chi-square test, t-test, intention-to-treat analysis, and hierarchical generalized linear model were undertaken.
Results: A total of 408 children with 1,831 tooth surfaces with active dentine caries were recruited at baseline. No significant differences were found between two treatment groups at baseline. At the 24-month evaluation, 356 children (87%) with 1,607 tooth surfaces (88%) were examined. No difference was found in dropout rates between groups. The arrest rates at the tooth-surface level were 42% in Group A (without fTCP) and 57% in Group B (with fTCP) (p<0.001). Results of the hierarchical generalized linear model showed that active carious tooth surfaces treated in Group B (with fTCP) had a higher chance of being arrested than those treated in Group A (without fTCP) (OR=1.91; CI:1.01, 3.60, p=0.046). In addition, tooth-surface type, tooth location, presence of dental plaque, and monthly family income were related to caries arrest rate (p<0.05).
Conclusions: Semi-annual application of a 25% AgNO3 solution followed by a 5% NaF varnish with fTCP is more effective in arresting dentine caries of primary dentition than that of a 25% AgNO3 solution followed by a 5% NaF varnish without fTCP (ClinicalTrial.gov: NCT03423797).