Gardenia Jasminoides Increases Fibroblast and Collagen in Post-Extraction Tooth Socket Healing
Objectives: To know the potency of Gardenia jasminoides extract in increasing the amount of fibroblast and collagen in Wistar rat’s post-extraction tooth socket healing.
Methods: In vivo laboratory experimental research of 3-month-old male Wistar rats (n=7/gp) divided into 4 groups (K1, P1, K2, and P2), each rat’s left mandible incisive was extracted. The treated groups were given Gardenia jasminoides leaf extract gel 3%, terminated (3rd and 5th day), stained (HE for fibroblast counting and IHC for collagen-1 measuring), and analyzed (normality, homogenity, independent T, and Pearson test).
Results: Fibroblast increased significantly (p<0.05) on groups given Gardenia jasminoides 3% extract (P1=14.571; P2=16.714) compared to control groups (K1=8.286; K2=9.286), either on the 3rd day or the 5th day post-extraction. Collagen-1 expression on groups given Gardenia jasminoides 3% extract (P1=14.286; P2=18.714) was greater compared to control groups (K1=5.428; K2=7.857). In addition, the result of both variables on the 5th day was higher than on the 3rd day.
Conclusions: Gardenia jasminoides extract has been proven to increase the amount of fibroblast and expression of type I collagen of Wistar rat’s tooth socket healing process post-extraction, and both variables have a positive correlation.