Collagen Sponge Stimulated Bone Repair in Ovariectomized Rat

Objectives: To investigate the osteoinductive effect of absorable collagen sponge on calvarial defect healing in ovariectomized rat
Methods: Fourteen 5-month old female Sprague-Dawley rats were ovariectomized. After one month of post-operation, the 7 mm diameter calvarial defect were performed and equally divided into blood clot control and collagen sponge treated group. At one month of treatment, the calvarial specimens were obtained and evaluated using micro-computed tomography for bone volume fraction (BVF) and histopathology. The data were evaluated using SPSS version 17. The p value for significance was set at 0.05.
Results: The ovariectomized rat show a steady changes in body weights. The collgen sponge treated group had a significant increase in bone volume fraction compared with control (p<0.05). Histopahtological data demonstrated no cellular infiltrate in both groups. The well-integration of collagen sponge with the bone matrix was observed.
Conclusions: Collgen sponge swifted calvarial bone repair in ovarectomized rat at one month.