IADR Abstract Archives
Development of a Novel Glass-ionomer Cement Containing Silver Diamine Fluoride
Objectives: Glass-ionomer cement (GIC) has been a material of choice for Atraumatic Restorative Treatment (ART) for more than 30-years however, residual microorganisms in cavities still remained a concern for this technique. The objectives of this study were to improve the antibacterial activity of GIC by incorporating 38% silver diamine fluoride (SDF) at different concentration and to investigate physical properties including fluoride release of the potential formulation for future clinical application.
Methods: GIC (Fuji IX®) served as a control (C) while GIC incorporated with SDF (v/v of GIC-liquid) served as test groups (T, T1=5%, T2=12.5%, T3=25%). Antibacterial activity against Streptococcus mutans UA159 (n=6/group) was investigated by agar diffusion test and statistically analyzed (ANOVA, Scheffe post hoc, p<0.05). Setting time (n=3/group) and compressive strength (n=5/group) were tested and evaluated according to ISO9917-1:2007. Fluoride release (n=5/group) was determined using fluoride-ion electrode and statistically analyzed (independent sample t-test, p<0.05).
Results: T showed higher antibacterial activity than C (p<0.05) with no statistically significant difference among T. T1, the lightest color, was selected for the following tests. Setting time (4.8-5.3min) and compressive strength of T1 (130-156MPa) were within and above ISO requirement (1.5-6min, 100MPa respectively). There was no statistically significant difference of fluoride released between T1 (743±102ppm) and C (657±71ppm).
Conclusions: We successfully developed novel GICs with higher antibacterial activities compared to GIC. GIC containing SDF at 5% (v/v GIC-liquid) provided the best esthetic profile among the modified cements and met the ISO standard for setting time and compressive strength without deteriorating the GIC fluoride releasing pattern. This novel cement has a potential of being a restorative material for ART. However, bonding efficacy and biocompatibility of this novel GIC should be further investigated for future clinical application.
Methods: GIC (Fuji IX®) served as a control (C) while GIC incorporated with SDF (v/v of GIC-liquid) served as test groups (T, T1=5%, T2=12.5%, T3=25%). Antibacterial activity against Streptococcus mutans UA159 (n=6/group) was investigated by agar diffusion test and statistically analyzed (ANOVA, Scheffe post hoc, p<0.05). Setting time (n=3/group) and compressive strength (n=5/group) were tested and evaluated according to ISO9917-1:2007. Fluoride release (n=5/group) was determined using fluoride-ion electrode and statistically analyzed (independent sample t-test, p<0.05).
Results: T showed higher antibacterial activity than C (p<0.05) with no statistically significant difference among T. T1, the lightest color, was selected for the following tests. Setting time (4.8-5.3min) and compressive strength of T1 (130-156MPa) were within and above ISO requirement (1.5-6min, 100MPa respectively). There was no statistically significant difference of fluoride released between T1 (743±102ppm) and C (657±71ppm).
Conclusions: We successfully developed novel GICs with higher antibacterial activities compared to GIC. GIC containing SDF at 5% (v/v GIC-liquid) provided the best esthetic profile among the modified cements and met the ISO standard for setting time and compressive strength without deteriorating the GIC fluoride releasing pattern. This novel cement has a potential of being a restorative material for ART. However, bonding efficacy and biocompatibility of this novel GIC should be further investigated for future clinical application.