IADR Abstract Archives
Effects of Induction Mangosteen Peel Extract Combined with DFDBBX on Osteocalcyn, Collagen 1, and Osteoblast as Alveolar Bone Regeneration in Socket Preservation
Objectives: This research aimed to analyze the expression and level of osteocalcin, collagen 1 and osteoblast in extracted tooth socket filled with a combination of mangosteen peel extract and demineralized freeze-dried bovine bone xenograft (DFDBBX).
Methods: Fifty-six Cavia cobaya, which lower left incisors had been extracted, were divided into eight groups according to the substance used to fill their sockets on days 7 and 30. Poly ethylene Glicol, DFDBBX, mangosteen peel extract or a combination of mangosteen peel extract and DFDBBX were used in this experiment. This research then was conducted in several stages, the application of mangosteen peel extract combined with graft material was performed as the the form of tooth extraction socket preservation. The Cavia cobaya rats were subsequently examined by immunohistochemical method to measure osteocalcin and collagen 1 expressions, whereas histological examination was conducted to calculate the number of osteoblastsin in accordance with the duration of the research.
Results: On days 7 and 30, the group treated with a combination of DFDBBX and mangosteen peel extract had the highest expression and levels of osteocalcin, collagen 1, and osteoblasts.
Conclusions: The administration of mangosteen peel extract combined with DFDBBX as a means of tooth extraction socket preservation can increase osteocalcin and collagen 1 expression. Consequently, osteoblasts as a means of alveolar bone regeneration will increase in number.
Methods: Fifty-six Cavia cobaya, which lower left incisors had been extracted, were divided into eight groups according to the substance used to fill their sockets on days 7 and 30. Poly ethylene Glicol, DFDBBX, mangosteen peel extract or a combination of mangosteen peel extract and DFDBBX were used in this experiment. This research then was conducted in several stages, the application of mangosteen peel extract combined with graft material was performed as the the form of tooth extraction socket preservation. The Cavia cobaya rats were subsequently examined by immunohistochemical method to measure osteocalcin and collagen 1 expressions, whereas histological examination was conducted to calculate the number of osteoblastsin in accordance with the duration of the research.
Results: On days 7 and 30, the group treated with a combination of DFDBBX and mangosteen peel extract had the highest expression and levels of osteocalcin, collagen 1, and osteoblasts.
Conclusions: The administration of mangosteen peel extract combined with DFDBBX as a means of tooth extraction socket preservation can increase osteocalcin and collagen 1 expression. Consequently, osteoblasts as a means of alveolar bone regeneration will increase in number.