IADR Abstract Archives
Analysis of Serum Zinc and Copper Levels in Patients with Oral Potentially Malignant Disorders: A Cross-Sectional Study
Objectives: Analyzing the levels of these trace elements may help in early diagnosis, improving the prognosis and the efficacy of the treatment in oral potentially malignant disorders (OPMDs). The purpose of the current study is to evaluate the changes in the levels of serum Cu and Zn levels and to relate these alterations with the severity and progression of the OPMDs.
Methods: In this institutional-based study, 20 of each clinically diagnosed cases of OSMF, Leukoplakia, Erosive lichen planus and 20 healthy age and sex matched controls were taken. The subjects were screened properly and an informed consent was obtained from all the patients and controls following which blood samples were collected. After serum separation, analysis for Cu and Zn was done.
Results: Serum Copper (Cu) levels were found to be significantly increased in patients with OSMF, Leukoplakia, Erosive lichen planus and Serum Zinc (Zn) levels were found to be depleted in patients when compared to the control group. Furthermore, a progressive trend was seen in the levels of serum Cu with the increasing grades of OSMF. No significant relation was observed in the levels of Zn with the disease progression in OSMF.
Conclusions: Levels of serum Cu and Serum Zn can be diagnostic in early evaluation of OPMDs. Increasing levels of serum Cu in the progressive grades of OSMF can be used as a marker of disease progression and severity.
Methods: In this institutional-based study, 20 of each clinically diagnosed cases of OSMF, Leukoplakia, Erosive lichen planus and 20 healthy age and sex matched controls were taken. The subjects were screened properly and an informed consent was obtained from all the patients and controls following which blood samples were collected. After serum separation, analysis for Cu and Zn was done.
Results: Serum Copper (Cu) levels were found to be significantly increased in patients with OSMF, Leukoplakia, Erosive lichen planus and Serum Zinc (Zn) levels were found to be depleted in patients when compared to the control group. Furthermore, a progressive trend was seen in the levels of serum Cu with the increasing grades of OSMF. No significant relation was observed in the levels of Zn with the disease progression in OSMF.
Conclusions: Levels of serum Cu and Serum Zn can be diagnostic in early evaluation of OPMDs. Increasing levels of serum Cu in the progressive grades of OSMF can be used as a marker of disease progression and severity.