Adjunctive 660 nm Light-Emitting Diodes Irradiation During the Non-Surgical Periodontal Therapy: A Split-Mouth Cross over Clinical Trail

Objectives: To confirm the additional clinical outcome of adjunctive 660 nm irradiation during the non-surgical periodontal therapy.
Methods: Patients with at least one periodontitis-involved tooth in either three quadrants were recruited, and three protocols of LED light irradiation, including LED01 sites received LED light irradiation from initial clinical assessment (T0) until the completion of scaling and root planning (T1), LED02 sites received LED light irradiation from T1 until the date of re-evaluation (T2), and control sites received no LED light irradiation, were randomly assigned to each quadrant during the non-surgical periodontal therapy. Clinical parameters were assessed at T0 and T2, and biomarkers, including IL-1b and MMP-8, from gingival crevicular fluid were assessed at T0, T1, and T2.
Results: 19 of 21 participants completed the full treatment course. All examined sites revealed reduced probing pocket depth (PD), clinical attachment level (CAL), gingival index (GI), and plaque index (PI) with increased gingival recession (REC) at T2. LED01 and LED02 sites showed slightly greater PD reduction and CAL gain than the control sites. In LED02 sites, decreasing of MMP-8 was more prominent at T1 and T2, and the decrease of IL-1b was slightly greater in T1 when compared to the control sites.
Conclusions: LED light irradiation assisted the recovery of periodontium and can be used as an adjunctive treatment for non-surgical periodontal therapy.