IADR Abstract Archives
Zinc Partial Stabilized Cement for Vital Pulp Therapy
Objectives: Vital pulp therapy has been promoted in treating reversible pulpal injury. While current materials in clinical use had several limitations. Therefore, the aim of this study was to develop novel material: Zn partial stabilized cement (PSC) for Vital Pulp Therapy.
Methods: We used sol-gel method to prepare Zn PSC, and mixed with γ-PGA hydrogel. XRD, FTIR ,SEM, micro-hardness, mechanical properties, ion release, pH value were used to evaluate the chemical and physical properties of the materials for finding the optimal composition.
Results: The XRD analysis showed Zn2SiO4, ZnO, CaO, Ca3SiO5 and Ca2SiO4, were the main composition of Zn PSC, and Ca3SiO5 were mainly in monoclinic phase. ZnO peak increased with more Zn concentration, and γ-PGA addition did not affect the crystallinity of Zn PSC. It shows that the PSC cements with different zinc concentrations were successfully prepared by the sol-gel method. SEM examination showed that the higher the concentration of zinc added, the more difficulty to refine the powder. The addition of Zn reduced the setting time, and all PSC with different zinc concentrations showed shorter setting time compared to MTA. As zinc content increased, the compressive strength decreased slightly; and with γ-PGA increased, the compressive strength increased. Both ions' releasing concentration increased with time, and γ- PGA could effectively block the release of calcium ion. The pH value examined in PBS and SBF solution showed Zn PSC / γ- PGA hydrogel materials were more close to the human body's original pH compared to MTA .
Conclusions: Zn PSC mixed with γ-PGA hydrogel showed promising results in physical-chemical and mechanical properties, antibacterial/biocompatibility test and animal experiment will be performed for further evaluation.
Methods: We used sol-gel method to prepare Zn PSC, and mixed with γ-PGA hydrogel. XRD, FTIR ,SEM, micro-hardness, mechanical properties, ion release, pH value were used to evaluate the chemical and physical properties of the materials for finding the optimal composition.
Results: The XRD analysis showed Zn2SiO4, ZnO, CaO, Ca3SiO5 and Ca2SiO4, were the main composition of Zn PSC, and Ca3SiO5 were mainly in monoclinic phase. ZnO peak increased with more Zn concentration, and γ-PGA addition did not affect the crystallinity of Zn PSC. It shows that the PSC cements with different zinc concentrations were successfully prepared by the sol-gel method. SEM examination showed that the higher the concentration of zinc added, the more difficulty to refine the powder. The addition of Zn reduced the setting time, and all PSC with different zinc concentrations showed shorter setting time compared to MTA. As zinc content increased, the compressive strength decreased slightly; and with γ-PGA increased, the compressive strength increased. Both ions' releasing concentration increased with time, and γ- PGA could effectively block the release of calcium ion. The pH value examined in PBS and SBF solution showed Zn PSC / γ- PGA hydrogel materials were more close to the human body's original pH compared to MTA .
Conclusions: Zn PSC mixed with γ-PGA hydrogel showed promising results in physical-chemical and mechanical properties, antibacterial/biocompatibility test and animal experiment will be performed for further evaluation.