IADR Abstract Archives
Toothpaste Amount and Post-brushing Rinsing Affected Salivary Fluoride Retention
Objectives: Fluoride toothpaste has been used for dental caries prevention. There are many regimens for tooth brushing and rinsing procedures to prolong fluoride retention in the mouth. We investigated the pharmacokinetic parameters for efficient use.
Methods: 21 healthy subjects participated in a randomized crossover study. The subjects brushed their teeth with modified bass technique with 1,000 ppm fluoride toothpaste for 7 days before experiment. The three brushing procedures were brushing with 1 g (B1), 0.3 g (B0.3) of toothpaste without rinsing (only expectoration) and brushing with 1 g of toothpaste with expectoration followed by 10 seconds, 5 ml water rinsing (B1R). Each method was separated by 3 days (washout period). Unstimulated whole saliva was collected and measured for salivary fluoride concentration and salivary flow rate before brushing as a baseline and at 0, 5, 10, 30, 60, and 90 minutes after each brushing procedure. Data were tested using ANOVA.
Results: The salivary fluoride concentration and amount of soluble fluoride of B1 group were significantly higher than B0.3 and B1R group. The B1 and B1R groups prolonged the remineralizing level up to 60 minutes while the B0.3 group retained for 30 minutes. The t1/2 of fluoride concentration was 2 phases; initial phase which fluoride rapidly decreased from 0-10 minutes and late phase which fluoride slowly decreased from 30-90 minutes. The initial t1/2 of B1 and B1R group were significantly longer than B0.3 group. The late t1/2 of B0.3 group was significantly longer than B1 group. There was no statistical difference of salivary flow rate among all groups.
Conclusions: Non rinsing and the amount of F toothpaste play important roles in raising salivary F and prolonging the remineralizing level in oral cavity.
Methods: 21 healthy subjects participated in a randomized crossover study. The subjects brushed their teeth with modified bass technique with 1,000 ppm fluoride toothpaste for 7 days before experiment. The three brushing procedures were brushing with 1 g (B1), 0.3 g (B0.3) of toothpaste without rinsing (only expectoration) and brushing with 1 g of toothpaste with expectoration followed by 10 seconds, 5 ml water rinsing (B1R). Each method was separated by 3 days (washout period). Unstimulated whole saliva was collected and measured for salivary fluoride concentration and salivary flow rate before brushing as a baseline and at 0, 5, 10, 30, 60, and 90 minutes after each brushing procedure. Data were tested using ANOVA.
Results: The salivary fluoride concentration and amount of soluble fluoride of B1 group were significantly higher than B0.3 and B1R group. The B1 and B1R groups prolonged the remineralizing level up to 60 minutes while the B0.3 group retained for 30 minutes. The t1/2 of fluoride concentration was 2 phases; initial phase which fluoride rapidly decreased from 0-10 minutes and late phase which fluoride slowly decreased from 30-90 minutes. The initial t1/2 of B1 and B1R group were significantly longer than B0.3 group. The late t1/2 of B0.3 group was significantly longer than B1 group. There was no statistical difference of salivary flow rate among all groups.
Conclusions: Non rinsing and the amount of F toothpaste play important roles in raising salivary F and prolonging the remineralizing level in oral cavity.