IADR Abstract Archives
The Hepatoprotective Effect of Carrot Juice in Mice Induced by Paracetamol
Objectives: The aim of this research was to investigate the hepatoprotective effect of carrot juice against paracetamol induced hepatic damaged in mice.
Methods: The samples (n=35) were randomly divided into five group samples : the negative control group (aquades), the positive control group (parasetamol and sterillized saline) and the three different dose of carrot juice groups (5,10,20 ml/kgBW). Samples were treated based on five groups samples for the next 6 days. At the sixth day, samples were given paracetamol 400mg/kgBW to induced hepatotoxicity. After 18 hours of fasting, the day after (seventh day), samples were killed and their blood were laboratorically tested for SGOT and SGPT marker. The result of SGOT dan SGPT marker of mice by five different groups samples then statistically analyzed (Kruskal-wallis Test, p<0.05).
Results: The result showed that the carrot juice had the hepatoprotective effect against paracetamol induced hepatic damaged in mice. Pretreatment with carrot juice at dose of 20ml/kgBW prevented paracetamol induced rise in SGOT and SGPT better than 5ml/kgBW and 10ml/kgBW doses.
Conclusions: The higher dose of carrot juice had the better potency against the hepatotoxicity.
Methods: The samples (n=35) were randomly divided into five group samples : the negative control group (aquades), the positive control group (parasetamol and sterillized saline) and the three different dose of carrot juice groups (5,10,20 ml/kgBW). Samples were treated based on five groups samples for the next 6 days. At the sixth day, samples were given paracetamol 400mg/kgBW to induced hepatotoxicity. After 18 hours of fasting, the day after (seventh day), samples were killed and their blood were laboratorically tested for SGOT and SGPT marker. The result of SGOT dan SGPT marker of mice by five different groups samples then statistically analyzed (Kruskal-wallis Test, p<0.05).
Results: The result showed that the carrot juice had the hepatoprotective effect against paracetamol induced hepatic damaged in mice. Pretreatment with carrot juice at dose of 20ml/kgBW prevented paracetamol induced rise in SGOT and SGPT better than 5ml/kgBW and 10ml/kgBW doses.
Conclusions: The higher dose of carrot juice had the better potency against the hepatotoxicity.