IADR Abstract Archives
Imaging features to predict development of bisphosphonate-related osteonecrosis of jaw
Objectives: Although the imaging features of bisphosphonate-related osteonecrosis of the jaw (BRONJ) have been described, their use as predictive indices for the development of BRONJ has not been established. The purpose of this study was to clarify which panoramic radiographic features can predict the development of BRONJ.
Methods: Subjects consisted of 24 patients medicated with bisphosphonate (BP) for osteoporosis who developed osteonecrosis of the jaw (ONJ+ group). Controls consisted of 179 patients medicated with BP who did not have osteonecrosis (ONJ- group) and 200 patients who had no history of BP administration (unmedicated group). The mandibular cortical width (MCW), mandibular cortical index (MCI), sclerosis of trabecular bone, and thickening of the lamina dura were evaluated by panoramic radiography.
Results: The MCW was significantly smaller in the ONJ– group than in the other groups. Class II MCI (semilunar defects of endosteal margin) was frequently recorded on the affected and contralateral sides in the ONJ+ group, but not in the ONJ- and unmedicated groups. Sclerosis of the trabecular bone was significantly more frequently observed on the affected side in the ONJ+ group than in the other groups. Thickening of the lamina dura was observed significantly more frequently in the BP-treated groups than in the unmedicated group.
Conclusions: Class II MCI could be an indicator to predict the development of BRONJ. Sclerosis of trabecular bone was considered to be a resultant imaging feature of BRONJ. Thickening of the lamina dura could be an imaging feature caused by BP administration.p
Methods: Subjects consisted of 24 patients medicated with bisphosphonate (BP) for osteoporosis who developed osteonecrosis of the jaw (ONJ+ group). Controls consisted of 179 patients medicated with BP who did not have osteonecrosis (ONJ- group) and 200 patients who had no history of BP administration (unmedicated group). The mandibular cortical width (MCW), mandibular cortical index (MCI), sclerosis of trabecular bone, and thickening of the lamina dura were evaluated by panoramic radiography.
Results: The MCW was significantly smaller in the ONJ– group than in the other groups. Class II MCI (semilunar defects of endosteal margin) was frequently recorded on the affected and contralateral sides in the ONJ+ group, but not in the ONJ- and unmedicated groups. Sclerosis of the trabecular bone was significantly more frequently observed on the affected side in the ONJ+ group than in the other groups. Thickening of the lamina dura was observed significantly more frequently in the BP-treated groups than in the unmedicated group.
Conclusions: Class II MCI could be an indicator to predict the development of BRONJ. Sclerosis of trabecular bone was considered to be a resultant imaging feature of BRONJ. Thickening of the lamina dura could be an imaging feature caused by BP administration.p