Extract From Aloe vera Induced Tooth Socket Healing: A 13 - months Evaluation

Objectives: To investigate the effect of acemannan - a polysaccharide extracted from Aloe vera in human tooth socket healing at 3^rd, 6^th and 13^rd month of post-surgical extraction of mandibular impacted third molars, using Cone - Beam Computed Tomography (CBCT)
Methods: 18-25 year - old healthy patients participated in this randomized control trial. After atraumatic surgical removal of mandibular partial impacted third molars, the sockets were randomly treated with blood clot as control group or acemannan sponge. CBCT of the mandible were obtained immediately, after 3, 6, and 13 months post-experiment. The bone formation rate was evaluated by the percentage decrease of the socket volume (ΔV).
Results: 20 patients with 22 mandibular partial impacted third molars (10 control, 12 acemannan treated) were enrolled in this trial. Neither any side - effect nor secondary post-operation infection was recorded within one week. Both acemannan and control group have the significant decrease of total socket volume after 3, 6, and 13 months post-operation compared with immediate post-operation (p<0.05). Acemannan - treated group has the percentage decrease of total socket volume greater than that of control group at 3^rd, 6^th and 13^rd months post-experiment about 1.42, 1.14 and 1.12 folds, respectively (p<0.05).
Conclusions: Acemannan significantly increased the bone healing after partial impacted, lower third molar after 3, 6 and 13 months post-surgery compared with that of blood clot control group using 3D - evaluation technique.