Semi-purified Extract Of Guyabano (Annona muricata) Leaves As Oral Sedatives

Objectives: The thrust of the study is to determine the Guyabano leaves extract can be used as oral sedatives.
Methods: Experimental method was utilized. The physical and chemical characteristics of the extract was determined. Three rats per group were used for the experiment. Group 1 (Diazepam) positive control group, Group 2 (Guyabano extract) experimental group and Group 3 (Saline) as Negative control group were used. Biological test was evaluated through open-filed test, tail suspension test and righting reflex.
Results: Positive result in the test for flavanoids. The results further revealed that the higher the concentration of dose for group 1 and group 2 , the faster time the test animal become stationary, less mobile and more calm. Group 3 has no effect on the three biologic test upon administration of Normal Saline solution.
Conclusions: Guyabano leaves extract has flavanoids and can be used as an oral sedative