IADR Abstract Archives
Association between Human Leucocyte Antigens and Aggressive Periodontitis.
Objectives: The aim of this study was to evaluate human leukocyte antigen (HLA) associations in patients with aggressive periodontitis (age<45, N=57) in comparison to healthy controls (no periodontitis, age≥50, N=36) and general Thai population (N=650).
Methods: HLA-A, and -B were determined using reverse sequence-specific oligonucleotide probes hybridization technique. Statistical analyses were carried out by comparing each HLA allele frequency among cases, controls and general Thai population using Fisher's exact test and calculated odds ratios (OR) and 95% confidence intervals (CI).
Results: In comparison with the healthy controls, HLA-B*40:01 occurred more frequently in the patients with aggressive periodontitis (21.1% versus 2.8%, OR=9.3, 95%CI 1.2-75.3, P=0.013). In contrast, HLA-A*24:02 occurred less frequently in the patients with aggressive periodontitis (15.8% versus 36.1%, OR=0.3, 95%CI 0.1-0.9, P=0.043). In comparison with general Thai population, HLA-B*40:01 occurred more frequently in the patients with aggressive periodontitis (21.1% versus 10.8%, OR=2.2, 95%CI 1.1-4.6, P=0.029). While HLA-A*24:02 occurred more frequently in the healthy controls than in general Thai population (36.1% versus 20.5%, OR=2.2, 95%CI 1.0-4.7, P=0.035). There was no significant relationship between the other HLA alleles and aggressive periodontitis.
Conclusions: HLA-B*40:01 could be a putative risk allele, whereas HLA-A*24:02 could be a protective allele for aggressive periodontitis in Thais.
Methods: HLA-A, and -B were determined using reverse sequence-specific oligonucleotide probes hybridization technique. Statistical analyses were carried out by comparing each HLA allele frequency among cases, controls and general Thai population using Fisher's exact test and calculated odds ratios (OR) and 95% confidence intervals (CI).
Results: In comparison with the healthy controls, HLA-B*40:01 occurred more frequently in the patients with aggressive periodontitis (21.1% versus 2.8%, OR=9.3, 95%CI 1.2-75.3, P=0.013). In contrast, HLA-A*24:02 occurred less frequently in the patients with aggressive periodontitis (15.8% versus 36.1%, OR=0.3, 95%CI 0.1-0.9, P=0.043). In comparison with general Thai population, HLA-B*40:01 occurred more frequently in the patients with aggressive periodontitis (21.1% versus 10.8%, OR=2.2, 95%CI 1.1-4.6, P=0.029). While HLA-A*24:02 occurred more frequently in the healthy controls than in general Thai population (36.1% versus 20.5%, OR=2.2, 95%CI 1.0-4.7, P=0.035). There was no significant relationship between the other HLA alleles and aggressive periodontitis.
Conclusions: HLA-B*40:01 could be a putative risk allele, whereas HLA-A*24:02 could be a protective allele for aggressive periodontitis in Thais.