IADR Abstract Archives
Periodontal Inflammatory Disease is Associated with Risk of Parkinson’s Disease
Objectives: The cause-effect relation between periodontal inflammatory disease (PID) and Parkinson’s disease (PD) remains uncertain. The purpose of our study was to investigate the association between PID and PD.
Methods: We conducted a retrospective matched-cohort study by using Taiwan’s National Health Insurance Research Database. We identified 5,396 patients with newly diagnosed PID during 1997 to 2004 and 10792 cases without PID by matching sex, age, index of year, and comorbidity. Cox proportional hard regression was used to evaluate the risk of subsequent PD.
Results: A total 176 (3.26%) and 275 (2.55%) patients were diagnosed with PD in the case and control cohorts, respectively (Figure 1). It shows the Cox regression analysis of risk factors associated with development of PD. More PD development in case-cohort compared with control cohort was noted and the adjusted hazard ratio (HR) was 1.431 (95% CI=1.141-1.794, p = 0.002). This study shows subgroups stratified by gender, age, comorbidities, the Charlson Comorbidity Index (CCI) score and urbanization level during a 1-year period. The incidence rate ratio (IRR) of PD was significantly higher among the case cohort than it was among the control cohort, in the following subgroups: male gender, age ≥ 60 years, hypertension, stroke, CCI score 1, and CCI score ≥ 3. Both the patients with and without hyperlipidemia, chronic kidney disease, and traumatic brain injury in the case group were at higher risk of PD than were the control group. Level 1 and level 2 carried greater significant risk than did level 3 in terms of urbanization. However, PID subjects who were male, aged ≥ 70 years, hypertension, no hyperlipidemia, no depression, stroke, with/without chronic kidney disease, traumatic brain injury, CCI score ≥ 3, and the highest urbanization level 1, were associated with significant higher risk of PD after adjusting the HR. The difference between the case and control groups reached statistical significance difference between the case and control group in the 1st year of follow-up (p < 0.05 with log-rank test) (Figure 2).
Conclusions: Our results show that PID is associated with an increased risk of developing PD. These findings emphasize the importance of early prevention of PD by diminishing PID.
Methods: We conducted a retrospective matched-cohort study by using Taiwan’s National Health Insurance Research Database. We identified 5,396 patients with newly diagnosed PID during 1997 to 2004 and 10792 cases without PID by matching sex, age, index of year, and comorbidity. Cox proportional hard regression was used to evaluate the risk of subsequent PD.
Results: A total 176 (3.26%) and 275 (2.55%) patients were diagnosed with PD in the case and control cohorts, respectively (Figure 1). It shows the Cox regression analysis of risk factors associated with development of PD. More PD development in case-cohort compared with control cohort was noted and the adjusted hazard ratio (HR) was 1.431 (95% CI=1.141-1.794, p = 0.002). This study shows subgroups stratified by gender, age, comorbidities, the Charlson Comorbidity Index (CCI) score and urbanization level during a 1-year period. The incidence rate ratio (IRR) of PD was significantly higher among the case cohort than it was among the control cohort, in the following subgroups: male gender, age ≥ 60 years, hypertension, stroke, CCI score 1, and CCI score ≥ 3. Both the patients with and without hyperlipidemia, chronic kidney disease, and traumatic brain injury in the case group were at higher risk of PD than were the control group. Level 1 and level 2 carried greater significant risk than did level 3 in terms of urbanization. However, PID subjects who were male, aged ≥ 70 years, hypertension, no hyperlipidemia, no depression, stroke, with/without chronic kidney disease, traumatic brain injury, CCI score ≥ 3, and the highest urbanization level 1, were associated with significant higher risk of PD after adjusting the HR. The difference between the case and control groups reached statistical significance difference between the case and control group in the 1st year of follow-up (p < 0.05 with log-rank test) (Figure 2).
Conclusions: Our results show that PID is associated with an increased risk of developing PD. These findings emphasize the importance of early prevention of PD by diminishing PID.
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