IADR Abstract Archives
Anti-Porphyromonas gingivalis Activity of Salivary Lactobacilli in Periodontal Health and Disease
Objectives: Lactobacilli play an important role in maintaining oral health by balancing oral microflora. Porphyromonas gingivalis (P.gingivalis) is one of the most virulent pathogens, detected in chronic periodontitis. However, the anti-P.gingivalis activity of salivary lactobacilli in periodontal health and disease has not been thoroughly investigated. The present study aimed to identify salivary lactobacilli from subjects having either non-chronic periodontitis or chronic periodontitis, and to test their anti-P.gingivalis activities.
Methods: Lactobacilli play an important role in maintaining oral health by balancing oral microflora. Porphyromonas gingivalis (P.gingivalis) is one of the most virulent pathogens, detected in chronic periodontitis. However, the anti-P.gingivalis activity of salivary lactobacilli in periodontal health and disease has not been thoroughly investigated. The present study aimed to identify salivary lactobacilli from subjects having either non-chronic periodontitis or chronic periodontitis, and to test their anti-P.gingivalis activities.
Results: We found no significant differences in the total amount of salivary lactobacilli isolated from subjects with non-chronic periodontitis, compared to those with chronic periodontitis. All isolated lactobacilli belonging to 15 species were identified. Among fifteen Lactobacillus species, L. rhamnosus was less prevalent in chronic periodontitis patients, compared with non-chronic periodontitis subjects (p<0.05). All identified species, except L.brevis, had anti-P.gingivalis activity. L.salivarius, L.agilis, L.casei, L.pentosus, L.plantarum, L.rhamnosus, and L.fermentum had anti-P.gingivalis activity in negative correlation with the prevalence of chronic periodontitis (p<0.05). In addition, L.plantarum and L.pentosus had the most effective anti-P.gingivalis activity.
Conclusions: These findings suggest that L.plantarum and L.pentosus could be potential targets for the development of anti-P.gingivalis products in the future.
Methods: Lactobacilli play an important role in maintaining oral health by balancing oral microflora. Porphyromonas gingivalis (P.gingivalis) is one of the most virulent pathogens, detected in chronic periodontitis. However, the anti-P.gingivalis activity of salivary lactobacilli in periodontal health and disease has not been thoroughly investigated. The present study aimed to identify salivary lactobacilli from subjects having either non-chronic periodontitis or chronic periodontitis, and to test their anti-P.gingivalis activities.
Results: We found no significant differences in the total amount of salivary lactobacilli isolated from subjects with non-chronic periodontitis, compared to those with chronic periodontitis. All isolated lactobacilli belonging to 15 species were identified. Among fifteen Lactobacillus species, L. rhamnosus was less prevalent in chronic periodontitis patients, compared with non-chronic periodontitis subjects (p<0.05). All identified species, except L.brevis, had anti-P.gingivalis activity. L.salivarius, L.agilis, L.casei, L.pentosus, L.plantarum, L.rhamnosus, and L.fermentum had anti-P.gingivalis activity in negative correlation with the prevalence of chronic periodontitis (p<0.05). In addition, L.plantarum and L.pentosus had the most effective anti-P.gingivalis activity.
Conclusions: These findings suggest that L.plantarum and L.pentosus could be potential targets for the development of anti-P.gingivalis products in the future.