IADR Abstract Archives
Stichopus hermanii protects bone by reducing osteoclast in orthodontic movement
Objectives: Stichopus hermanii has various compounds such as EPA-DHA, calcium, Magnesium, Flavonoid and Triterpenoid, that may reduce the number of osteoclasts. Research Stichopus hermanii against osteoclasts in bone remodeling orthodontic tooth movement has not been investigated. This study examined Stichopus hermanii protects bone by reducing osteoclast in orthodontic movement.
Methods: Twenty-four male Cavia cobaya were divided into four groups. (K1) negative control for 6 days. (K2) positive control for 6 days by provision of separator and NaCMC gel. (P1 ) and (P2) were treated for 6 days by provision of separator and Stichopus hermanii gel 3% and 3.5%. Osteoclasts were calculated by histological preparations with HE staining and viewed using a light microscope with 400x magnification, and then analyzed by ANOVA followed by LSD test.
Results: The mean of osteoclasts K1, K2, P1, and P2 are (3.33 ± 1.211), (10.67 ± 1.211), (8.33 ± 0.816), and (4.33 ± 1.211). ANOVA showed a significant difference in the number of osteoclasts (p<0.001). LSD test showed significant differences in the number of osteoclasts in all groups.
Conclusions: Stichopus hermanii gel with a concentration of 3,5% more effective than 3% to protects bone by reducing the number of osteoclasts in orthodontic movement.
Methods: Twenty-four male Cavia cobaya were divided into four groups. (K1) negative control for 6 days. (K2) positive control for 6 days by provision of separator and NaCMC gel. (P1 ) and (P2) were treated for 6 days by provision of separator and Stichopus hermanii gel 3% and 3.5%. Osteoclasts were calculated by histological preparations with HE staining and viewed using a light microscope with 400x magnification, and then analyzed by ANOVA followed by LSD test.
Results: The mean of osteoclasts K1, K2, P1, and P2 are (3.33 ± 1.211), (10.67 ± 1.211), (8.33 ± 0.816), and (4.33 ± 1.211). ANOVA showed a significant difference in the number of osteoclasts (p<0.001). LSD test showed significant differences in the number of osteoclasts in all groups.
Conclusions: Stichopus hermanii gel with a concentration of 3,5% more effective than 3% to protects bone by reducing the number of osteoclasts in orthodontic movement.