IADR Abstract Archives
Effects of Gingivitis on Gingival Mesenchymal Stem Cells
Objectives: The aim of this study is to understand the effects of local inflammation (gingivitis) on the quantity of gingival mesenchymal stem cells (gMSCs) in healthy individuals.
Methods: Samples of healthy human gingival tissue were collected from 25 systemically healthy subjects. The samples were divided into subjects with healthy gingiva (control group) and– subjects with gingivitis (test group). These samples were examined by immunohistochemistry for CD105. Under the microscope with 40X magnification, 3 areas which were most densely populated by gMSC was chosen and quantified. The density of gMSCs was compared between the two groups.
Results: There was an increased number of gMSCs in tissues with gingivitis (30.22 ± 4.98 cells/mm2) compared to that of (24.54 ± 7.56 cells/mm2) in health gingival tissue (P = 0.038).
Conclusions: The number of gMSCs increases in the presence of local inflammation (gingivitis).
Methods: Samples of healthy human gingival tissue were collected from 25 systemically healthy subjects. The samples were divided into subjects with healthy gingiva (control group) and– subjects with gingivitis (test group). These samples were examined by immunohistochemistry for CD105. Under the microscope with 40X magnification, 3 areas which were most densely populated by gMSC was chosen and quantified. The density of gMSCs was compared between the two groups.
Results: There was an increased number of gMSCs in tissues with gingivitis (30.22 ± 4.98 cells/mm2) compared to that of (24.54 ± 7.56 cells/mm2) in health gingival tissue (P = 0.038).
Conclusions: The number of gMSCs increases in the presence of local inflammation (gingivitis).